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Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma.
Arch Pathol Lab Med. 1990 Apr; 114(4):429-31.AP

Abstract

A 48-year-old Japanese woman died of multiple myeloma (lambda light-chain type) with chronic renal failure. Histological examination revealed deposition of a homogeneous substance and crystals in the kidneys and thyroid gland. The homogeneous substance was stained with Congo red after permanganate treatment but did not stain with antibody to amyloid A protein, and it was recognized as AL-type amyloid. Crystals were not stained with Congo red, but crystals were stained with antibody to the lambda light chain. Since AL-type amyloid is considered to be derived from a myeloma light chain, the present case showed two different types of deposition, both of which were derived from the same myeloma protein.

Authors+Show Affiliations

Department of Pathology, Osaka University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2108650

Citation

Hirota, S, et al. "Crystalline Light-chain Deposition and Amyloidosis in the Thyroid Gland and Kidneys of a Patient With Myeloma." Archives of Pathology & Laboratory Medicine, vol. 114, no. 4, 1990, pp. 429-31.
Hirota S, Miyamoto M, Kasugai T, et al. Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma. Arch Pathol Lab Med. 1990;114(4):429-31.
Hirota, S., Miyamoto, M., Kasugai, T., Kitamura, Y., & Morimura, Y. (1990). Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma. Archives of Pathology & Laboratory Medicine, 114(4), 429-31.
Hirota S, et al. Crystalline Light-chain Deposition and Amyloidosis in the Thyroid Gland and Kidneys of a Patient With Myeloma. Arch Pathol Lab Med. 1990;114(4):429-31. PubMed PMID: 2108650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crystalline light-chain deposition and amyloidosis in the thyroid gland and kidneys of a patient with myeloma. AU - Hirota,S, AU - Miyamoto,M, AU - Kasugai,T, AU - Kitamura,Y, AU - Morimura,Y, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 429 EP - 31 JF - Archives of pathology & laboratory medicine JO - Arch. Pathol. Lab. Med. VL - 114 IS - 4 N2 - A 48-year-old Japanese woman died of multiple myeloma (lambda light-chain type) with chronic renal failure. Histological examination revealed deposition of a homogeneous substance and crystals in the kidneys and thyroid gland. The homogeneous substance was stained with Congo red after permanganate treatment but did not stain with antibody to amyloid A protein, and it was recognized as AL-type amyloid. Crystals were not stained with Congo red, but crystals were stained with antibody to the lambda light chain. Since AL-type amyloid is considered to be derived from a myeloma light chain, the present case showed two different types of deposition, both of which were derived from the same myeloma protein. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/2108650/Crystalline_light_chain_deposition_and_amyloidosis_in_the_thyroid_gland_and_kidneys_of_a_patient_with_myeloma_ L2 - http://www.diseaseinfosearch.org/result/380 DB - PRIME DP - Unbound Medicine ER -