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A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae.
Curr Opin Biotechnol. 2011 Apr; 22(2):150-6.CO

Abstract

The success of food and beverage production processes carried out by Saccharomyces cerevisiae and the thriving of food spoilage fungi are dependent on the ability of a cell to cope with the many environmental insults imposed during food production and preservation processes. Post-genomic approaches, especially transcriptomics, proteomics and chemogenomics, applied to S. cerevisiae made possible the unveiling of general and specific genome-wide adaptive response programs against stress induced by weak acids, ethanol, sulfite, heat and cold shock, osmotic pressure and nutrient limitation. These programs and the underlying signaling pathways are overviewed herein, highlighting the recent identification of genes and pathways found to be involved in stress response and tolerance. These are good candidate targets for genetic engineering aiming at the development of improved strains. The extension of the data gathered in S. cerevisiae to food spoilage fungi is considered. The relevance of the different genome-wide approaches in this context is also discussed.

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Authors+Show Affiliations

Teixeira MC
IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Technical University of Lisbon, 1049-001 Lisboa, Portugal.
Mira NP
No affiliation info available
Sá-Correia I
No affiliation info available

MeSH

Food MicrobiologyGene Expression Regulation, FungalGenetic EngineeringModels, BiologicalSaccharomyces cerevisiaeSignal Transduction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21087853

Citation

Teixeira, Miguel C., et al. "A Genome-wide Perspective On the Response and Tolerance to Food-relevant Stresses in Saccharomyces Cerevisiae." Current Opinion in Biotechnology, vol. 22, no. 2, 2011, pp. 150-6.
Teixeira MC, Mira NP, Sá-Correia I. A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae. Curr Opin Biotechnol. 2011;22(2):150-6.
Teixeira, M. C., Mira, N. P., & Sá-Correia, I. (2011). A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae. Current Opinion in Biotechnology, 22(2), 150-6. https://doi.org/10.1016/j.copbio.2010.10.011
Teixeira MC, Mira NP, Sá-Correia I. A Genome-wide Perspective On the Response and Tolerance to Food-relevant Stresses in Saccharomyces Cerevisiae. Curr Opin Biotechnol. 2011;22(2):150-6. PubMed PMID: 21087853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genome-wide perspective on the response and tolerance to food-relevant stresses in Saccharomyces cerevisiae. AU - Teixeira,Miguel C, AU - Mira,Nuno P, AU - Sá-Correia,Isabel, Y1 - 2010/11/16/ PY - 2010/07/29/received PY - 2010/10/15/revised PY - 2010/10/20/accepted PY - 2010/11/20/entrez PY - 2010/11/20/pubmed PY - 2011/8/4/medline SP - 150 EP - 6 JF - Current opinion in biotechnology JO - Curr Opin Biotechnol VL - 22 IS - 2 N2 - The success of food and beverage production processes carried out by Saccharomyces cerevisiae and the thriving of food spoilage fungi are dependent on the ability of a cell to cope with the many environmental insults imposed during food production and preservation processes. Post-genomic approaches, especially transcriptomics, proteomics and chemogenomics, applied to S. cerevisiae made possible the unveiling of general and specific genome-wide adaptive response programs against stress induced by weak acids, ethanol, sulfite, heat and cold shock, osmotic pressure and nutrient limitation. These programs and the underlying signaling pathways are overviewed herein, highlighting the recent identification of genes and pathways found to be involved in stress response and tolerance. These are good candidate targets for genetic engineering aiming at the development of improved strains. The extension of the data gathered in S. cerevisiae to food spoilage fungi is considered. The relevance of the different genome-wide approaches in this context is also discussed. SN - 1879-0429 UR - https://www.unboundmedicine.com/medline/citation/21087853/A_genome_wide_perspective_on_the_response_and_tolerance_to_food_relevant_stresses_in_Saccharomyces_cerevisiae_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0958-1669(10)00199-0 DB - PRIME DP - Unbound Medicine ER -