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β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.
The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM.
Authors, , , , , , , ,
Anti-Inflammatory Agents, Non-Steroidal
Inhibitory Concentration 50
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't