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β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.

Abstract

The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM.

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  • Publisher Full Text
  • Authors

    , , , , , , , ,

    Source

    Journal of natural products 73:12 2010 Dec 27 pg 1993-8

    MeSH

    Alkaloids
    Animals
    Anti-Inflammatory Agents, Non-Steroidal
    Carbolines
    Glycosides
    Inhibitory Concentration 50
    Lipopolysaccharides
    Macrophages
    Mice
    Molecular Structure
    Nitric Oxide
    Plant Roots
    Stellaria
    Stereoisomerism
    Taiwan

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21090796

    Citation

    TY - JOUR T1 - β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity. AU - Chen,Yuh-Fung, AU - Kuo,Ping-Chung, AU - Chan,Hsiu-Hui, AU - Kuo,I-Je, AU - Lin,Fu-Wen, AU - Su,Chung-Ren, AU - Yang,Mei-Lin, AU - Li,Ding-Tzai, AU - Wu,Tian-Shung, Y1 - 2010/11/23/ PY - 2010/11/23/aheadofprint PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/1/28/medline SP - 1993 EP - 8 JF - Journal of natural products JO - J. Nat. Prod. VL - 73 IS - 12 N2 - The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/21090796/β_carboline_alkaloids_from_Stellaria_dichotoma_var__lanceolata_and_their_anti_inflammatory_activity_ L2 - http://dx.doi.org/10.1021/np1003627 ER -