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β-carboline alkaloids from Stellaria dichotoma var. lanceolata and their anti-inflammatory activity.
The present investigation on the chemical constituents of the roots of Stellaria dichotoma var. lanceolata has resulted in the isolation of 21 β-carboline alkaloids, including 13 new compounds, dichotomides III-XIV (1-12) and dichotomine E (13), and eight known compounds. The structures of the new compounds were established on the basis of spectroscopic data analysis. Among these isolated alkaloids, five compounds were examined for their anti-inflammatory potential for the inhibition of NO production in LPS-treated RAW 264.7 cells. All compounds tested exhibited significant inhibition of NO production, with IC(50) values in the range of 11.3 to 19.3 μM.
Graduate Institute of Chinese Pharmaceutical Science, China Medical University, Taichung 401, Taiwan, Republic of China., , , , , , ,
Anti-Inflammatory Agents, Non-Steroidal
Inhibitory Concentration 50
Pub Type(s)Journal Article
Research Support, Non-U.S. Gov't