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Fluorescence diagnostic imaging in patients with acne.

Abstract

BACKGROUND

Orange-red fluorescence in the follicle openings, induced by ultraviolet A light, originates from porphyrins, the metabolic products of Propionibacteria acnes.

PURPOSE

To investigate the relationship of orange-red follicular fluorescence with the severity of acne and the amount of sebum secretion.

METHODS

Twenty-five volunteers were included. The severity of acne was rated on a 4-point scale. The casual sebum level was measured using a Sebumeter and the follicular fluorescence was determined using the camera Visiopor.

RESULTS

Casual sebum level and the intensity of fluorescence (percentage of the area and number of orange-red spots) were higher at the T zone than at the U zone in all patients regardless of their skin type. Sebum amount and area of fluorescence spots were significantly negative in correlation with the clinical grade of acne. There was a significant positive correlation between the orange-red fluorescence and the casual sebum level.

CONCLUSION

The orange-red fluorescence showed stronger correlation with the presence of non-inflammatory acne lesions (comedones) and high sebum amount than the presence of inflammatory acne lesions (pustules) and low sebum amount. The fluorescence diagnostic imaging could be useful in the objective evaluation and monitoring of treatment efficacy in subjects with acne-prone skin and patients with acne.

Authors+Show Affiliations

Department of Dermatology and Venereology, Medical University, Plovdiv, Bulgaria. hristo_dobrev@hotmail.com

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21091785

Citation

Dobrev, Hristo. "Fluorescence Diagnostic Imaging in Patients With Acne." Photodermatology, Photoimmunology & Photomedicine, vol. 26, no. 6, 2010, pp. 285-9.
Dobrev H. Fluorescence diagnostic imaging in patients with acne. Photodermatol Photoimmunol Photomed. 2010;26(6):285-9.
Dobrev, H. (2010). Fluorescence diagnostic imaging in patients with acne. Photodermatology, Photoimmunology & Photomedicine, 26(6), pp. 285-9. doi:10.1111/j.1600-0781.2010.00541.x.
Dobrev H. Fluorescence Diagnostic Imaging in Patients With Acne. Photodermatol Photoimmunol Photomed. 2010;26(6):285-9. PubMed PMID: 21091785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluorescence diagnostic imaging in patients with acne. A1 - Dobrev,Hristo, PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/3/10/medline SP - 285 EP - 9 JF - Photodermatology, photoimmunology & photomedicine JO - Photodermatol Photoimmunol Photomed VL - 26 IS - 6 N2 - BACKGROUND: Orange-red fluorescence in the follicle openings, induced by ultraviolet A light, originates from porphyrins, the metabolic products of Propionibacteria acnes. PURPOSE: To investigate the relationship of orange-red follicular fluorescence with the severity of acne and the amount of sebum secretion. METHODS: Twenty-five volunteers were included. The severity of acne was rated on a 4-point scale. The casual sebum level was measured using a Sebumeter and the follicular fluorescence was determined using the camera Visiopor. RESULTS: Casual sebum level and the intensity of fluorescence (percentage of the area and number of orange-red spots) were higher at the T zone than at the U zone in all patients regardless of their skin type. Sebum amount and area of fluorescence spots were significantly negative in correlation with the clinical grade of acne. There was a significant positive correlation between the orange-red fluorescence and the casual sebum level. CONCLUSION: The orange-red fluorescence showed stronger correlation with the presence of non-inflammatory acne lesions (comedones) and high sebum amount than the presence of inflammatory acne lesions (pustules) and low sebum amount. The fluorescence diagnostic imaging could be useful in the objective evaluation and monitoring of treatment efficacy in subjects with acne-prone skin and patients with acne. SN - 1600-0781 UR - https://www.unboundmedicine.com/medline/citation/21091785/Fluorescence_diagnostic_imaging_in_patients_with_acne_ L2 - https://doi.org/10.1111/j.1600-0781.2010.00541.x DB - PRIME DP - Unbound Medicine ER -