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A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes.
BMC Genomics. 2010 Nov 20; 11:647.BG

Abstract

BACKGROUND

The turkey (Meleagris gallopavo) is an important agricultural species that is the second largest contributor to the world's poultry meat production. The genomic resources of turkey provide turkey breeders with tools needed for the genetic improvement of commercial breeds of turkey for economically important traits. A linkage map of turkey is essential not only for the mapping of quantitative trait loci, but also as a framework to enable the assignment of sequence contigs to specific chromosomes. Comparative genomics with chicken provides insight into mechanisms of genome evolution and helps in identifying rare genomic events such as genomic rearrangements and duplications/deletions.

RESULTS

Eighteen full sib families, comprising 1008 (35 F1 and 973 F2) birds, were genotyped for 775 single nucleotide polymorphisms (SNPs). Of the 775 SNPs, 570 were informative and used to construct a linkage map in turkey. The final map contains 531 markers in 28 linkage groups. The total genetic distance covered by these linkage groups is 2,324 centimorgans (cM) with the largest linkage group (81 loci) measuring 326 cM. Average marker interval for all markers across the 28 linkage groups is 4.6 cM. Comparative mapping of turkey and chicken revealed two inter-, and 57 intrachromosomal rearrangements between these two species.

CONCLUSION

Our turkey genetic map of 531 markers reveals a genome length of 2,324 cM. Our linkage map provides an improvement of previously published maps because of the more even distribution of the markers and because the map is completely based on SNP markers enabling easier and faster genotyping assays than the microsatellitemarkers used in previous linkage maps. Turkey and chicken are shown to have a highly conserved genomic structure with a relatively low number of inter-, and intrachromosomal rearrangements.

Authors+Show Affiliations

Animal Breeding and Genomics Centre, Wageningen University, 6709PG, Wageningen, The Netherlands. muhammadl.aslam@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21092123

Citation

Aslam, Muhammad L., et al. "A SNP Based Linkage Map of the Turkey Genome Reveals Multiple Intrachromosomal Rearrangements Between the Turkey and Chicken Genomes." BMC Genomics, vol. 11, 2010, p. 647.
Aslam ML, Bastiaansen JW, Crooijmans RP, et al. A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes. BMC Genomics. 2010;11:647.
Aslam, M. L., Bastiaansen, J. W., Crooijmans, R. P., Vereijken, A., Megens, H. J., & Groenen, M. A. (2010). A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes. BMC Genomics, 11, 647. https://doi.org/10.1186/1471-2164-11-647
Aslam ML, et al. A SNP Based Linkage Map of the Turkey Genome Reveals Multiple Intrachromosomal Rearrangements Between the Turkey and Chicken Genomes. BMC Genomics. 2010 Nov 20;11:647. PubMed PMID: 21092123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A SNP based linkage map of the turkey genome reveals multiple intrachromosomal rearrangements between the turkey and chicken genomes. AU - Aslam,Muhammad L, AU - Bastiaansen,John W M, AU - Crooijmans,Richard P M A, AU - Vereijken,Addie, AU - Megens,Hendrik-Jan, AU - Groenen,Martien A M, Y1 - 2010/11/20/ PY - 2010/07/16/received PY - 2010/11/20/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/3/8/medline SP - 647 EP - 647 JF - BMC genomics JO - BMC Genomics VL - 11 N2 - BACKGROUND: The turkey (Meleagris gallopavo) is an important agricultural species that is the second largest contributor to the world's poultry meat production. The genomic resources of turkey provide turkey breeders with tools needed for the genetic improvement of commercial breeds of turkey for economically important traits. A linkage map of turkey is essential not only for the mapping of quantitative trait loci, but also as a framework to enable the assignment of sequence contigs to specific chromosomes. Comparative genomics with chicken provides insight into mechanisms of genome evolution and helps in identifying rare genomic events such as genomic rearrangements and duplications/deletions. RESULTS: Eighteen full sib families, comprising 1008 (35 F1 and 973 F2) birds, were genotyped for 775 single nucleotide polymorphisms (SNPs). Of the 775 SNPs, 570 were informative and used to construct a linkage map in turkey. The final map contains 531 markers in 28 linkage groups. The total genetic distance covered by these linkage groups is 2,324 centimorgans (cM) with the largest linkage group (81 loci) measuring 326 cM. Average marker interval for all markers across the 28 linkage groups is 4.6 cM. Comparative mapping of turkey and chicken revealed two inter-, and 57 intrachromosomal rearrangements between these two species. CONCLUSION: Our turkey genetic map of 531 markers reveals a genome length of 2,324 cM. Our linkage map provides an improvement of previously published maps because of the more even distribution of the markers and because the map is completely based on SNP markers enabling easier and faster genotyping assays than the microsatellitemarkers used in previous linkage maps. Turkey and chicken are shown to have a highly conserved genomic structure with a relatively low number of inter-, and intrachromosomal rearrangements. SN - 1471-2164 UR - https://www.unboundmedicine.com/medline/citation/21092123/A_SNP_based_linkage_map_of_the_turkey_genome_reveals_multiple_intrachromosomal_rearrangements_between_the_turkey_and_chicken_genomes_ L2 - https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-647 DB - PRIME DP - Unbound Medicine ER -