Tags

Type your tag names separated by a space and hit enter

Body mass interacts with fat quality to determine the postprandial lipoprotein response in healthy young adults.
Nutr Metab Cardiovasc Dis 2012; 22(4):355-61NM

Abstract

BACKGROUND AND AIMS

Postprandial lipemia predicts the evolution of cardiovascular disease. Obesity is associated with an increase in the magnitude of postprandial lipemia. Our objective was to evaluate the influence of body mass index (BMI) on the effects of acute ingestion of different types of fat on the postprandial lipemic response.

METHODS AND RESULTS

Twenty-one healthy men followed a 4-week baseline diet and then consumed three fat-loaded meals that included 1g fat/kg body wt (65%fat) according to a randomized crossover design. The compositions of the three meals were olive oil meal (22% saturated fatty acids (SFA), 38% monounsaturated fatty acids (MUFA), 4% polyunsaturated fatty acids (PUFA)); butter meal (35% SFA, 22% MUFA, 4% PUFA); walnuts meal (20% SFA, 24% MUFA, 16% PUFA, and 4% α-linolenic acid). Higher-weight (HW) subjects (BMI greater than the median 26.18 kg/m(2), n = 11) presented higher incremental area under the curve (iAUC) for triglycerides (TG), both in large- and small-TG rich lipoproteins (TRL) than lower-weight (LW) subjects (BMI<26.18 kg/m(2), n = 10) (p<0.05), and a similar trend for plasma TG (p = 0.084). Moreover, HW subjects presented higher concentrations for small TRL-cholesterol and small TRL-TG in different timepoints of the postprandial lipemia after the intake of enriched walnuts or butter meals compared with the olive oil-enriched meal (p < 0.05) No significant differences were observed between the three types of meals in the postprandial response of LW subjects.

CONCLUSION

HW subjects present a greater postprandial response than LW subjects, and they benefit from the consumption of monounsaturated fatty acids from olive oil, to lower their levels of TRL particles during the postprandial state.

Authors+Show Affiliations

Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21093231

Citation

Lozano, A, et al. "Body Mass Interacts With Fat Quality to Determine the Postprandial Lipoprotein Response in Healthy Young Adults." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 22, no. 4, 2012, pp. 355-61.
Lozano A, Perez-Martinez P, Delgado-Lista J, et al. Body mass interacts with fat quality to determine the postprandial lipoprotein response in healthy young adults. Nutr Metab Cardiovasc Dis. 2012;22(4):355-61.
Lozano, A., Perez-Martinez, P., Delgado-Lista, J., Marin, C., Cortes, B., Rodriguez-Cantalejo, F., ... Lopez-Miranda, J. (2012). Body mass interacts with fat quality to determine the postprandial lipoprotein response in healthy young adults. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 22(4), pp. 355-61. doi:10.1016/j.numecd.2010.07.013.
Lozano A, et al. Body Mass Interacts With Fat Quality to Determine the Postprandial Lipoprotein Response in Healthy Young Adults. Nutr Metab Cardiovasc Dis. 2012;22(4):355-61. PubMed PMID: 21093231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass interacts with fat quality to determine the postprandial lipoprotein response in healthy young adults. AU - Lozano,A, AU - Perez-Martinez,P, AU - Delgado-Lista,J, AU - Marin,C, AU - Cortes,B, AU - Rodriguez-Cantalejo,F, AU - Gomez-Luna,M J, AU - Cruz-Teno,C, AU - Perez-Jimenez,F, AU - Lopez-Miranda,J, Y1 - 2010/11/18/ PY - 2009/11/14/received PY - 2010/07/18/revised PY - 2010/07/22/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2012/7/24/medline SP - 355 EP - 61 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 22 IS - 4 N2 - BACKGROUND AND AIMS: Postprandial lipemia predicts the evolution of cardiovascular disease. Obesity is associated with an increase in the magnitude of postprandial lipemia. Our objective was to evaluate the influence of body mass index (BMI) on the effects of acute ingestion of different types of fat on the postprandial lipemic response. METHODS AND RESULTS: Twenty-one healthy men followed a 4-week baseline diet and then consumed three fat-loaded meals that included 1g fat/kg body wt (65%fat) according to a randomized crossover design. The compositions of the three meals were olive oil meal (22% saturated fatty acids (SFA), 38% monounsaturated fatty acids (MUFA), 4% polyunsaturated fatty acids (PUFA)); butter meal (35% SFA, 22% MUFA, 4% PUFA); walnuts meal (20% SFA, 24% MUFA, 16% PUFA, and 4% α-linolenic acid). Higher-weight (HW) subjects (BMI greater than the median 26.18 kg/m(2), n = 11) presented higher incremental area under the curve (iAUC) for triglycerides (TG), both in large- and small-TG rich lipoproteins (TRL) than lower-weight (LW) subjects (BMI<26.18 kg/m(2), n = 10) (p<0.05), and a similar trend for plasma TG (p = 0.084). Moreover, HW subjects presented higher concentrations for small TRL-cholesterol and small TRL-TG in different timepoints of the postprandial lipemia after the intake of enriched walnuts or butter meals compared with the olive oil-enriched meal (p < 0.05) No significant differences were observed between the three types of meals in the postprandial response of LW subjects. CONCLUSION: HW subjects present a greater postprandial response than LW subjects, and they benefit from the consumption of monounsaturated fatty acids from olive oil, to lower their levels of TRL particles during the postprandial state. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/21093231/Body_mass_interacts_with_fat_quality_to_determine_the_postprandial_lipoprotein_response_in_healthy_young_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(10)00186-9 DB - PRIME DP - Unbound Medicine ER -