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Degradation of the antibiotic amoxicillin by photo-Fenton process--chemical and toxicological assessment.
Water Res. 2011 Jan; 45(3):1394-402.WR

Abstract

The influence of iron species on amoxicillin (AMX) degradation, intermediate products generated and toxicity during the photo-Fenton process using a solar simulator were evaluated in this work. The AMX degradation was favored in the presence of the potassium ferrioxalate complex (FeOx) when compared to FeSO(4). Total oxidation of AMX in the presence of FeOx was obtained after 5 min, while 15 min were necessary using FeSO(4). The results obtained with Daphnia magna biossays showed that the toxicity decreased from 65 to 5% after 90 min of irradiation in the presence of FeSO(4). However, it increased again to a maximum of 100% after 150 min, what indicates the generation of more toxic intermediates than AMX, reaching 45% after 240 min. However, using FeOx, the inhibition of mobility varied between 100 and 70% during treatment, probably due to the presence of oxalate, which is toxic to the neonates. After 240 min, between 73 and 81% TOC removal was observed. Different pathways of AMX degradation were suggested including the opening of the four-membered β-lactamic ring and further oxidations of the methyl group to aldehyde and/or hydroxylation of the benzoic ring, generating other intermediates after bound cleavage between different atoms and further oxidation to carboxylates such acetate, oxalate and propionate, besides the generation of nitrate and ammonium.

Links

Publisher Full Text
linkinghub.elsevier.com
linkinghub.elsevier.com

Authors+Show Affiliations

Trovó AG
UNESP - Univ Estadual Paulista, Instituto de Química de Araraquara, CP 355, 14801-970, Araraquara, SP, Brazil.
Nogueira RF
No affiliation info available
Agüera A
No affiliation info available
Fernandez-Alba AR
No affiliation info available
Malato S
No affiliation info available

MeSH

AmoxicillinAnti-Bacterial AgentsHydrogen PeroxideHydrolysisIronOxidation-ReductionPhotochemistryWaste Disposal, FluidWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21093887

Citation

Trovó, Alam G., et al. "Degradation of the Antibiotic Amoxicillin By photo-Fenton Process--chemical and Toxicological Assessment." Water Research, vol. 45, no. 3, 2011, pp. 1394-402.
Trovó AG, Nogueira RF, Agüera A, et al. Degradation of the antibiotic amoxicillin by photo-Fenton process--chemical and toxicological assessment. Water Res. 2011;45(3):1394-402.
Trovó, A. G., Nogueira, R. F., Agüera, A., Fernandez-Alba, A. R., & Malato, S. (2011). Degradation of the antibiotic amoxicillin by photo-Fenton process--chemical and toxicological assessment. Water Research, 45(3), 1394-402. https://doi.org/10.1016/j.watres.2010.10.029
Trovó AG, et al. Degradation of the Antibiotic Amoxicillin By photo-Fenton Process--chemical and Toxicological Assessment. Water Res. 2011;45(3):1394-402. PubMed PMID: 21093887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degradation of the antibiotic amoxicillin by photo-Fenton process--chemical and toxicological assessment. AU - Trovó,Alam G, AU - Nogueira,Raquel F Pupo, AU - Agüera,Ana, AU - Fernandez-Alba,Amadeo R, AU - Malato,Sixto, Y1 - 2010/10/31/ PY - 2010/05/10/received PY - 2010/08/12/revised PY - 2010/10/25/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/4/22/medline SP - 1394 EP - 402 JF - Water research JO - Water Res VL - 45 IS - 3 N2 - The influence of iron species on amoxicillin (AMX) degradation, intermediate products generated and toxicity during the photo-Fenton process using a solar simulator were evaluated in this work. The AMX degradation was favored in the presence of the potassium ferrioxalate complex (FeOx) when compared to FeSO(4). Total oxidation of AMX in the presence of FeOx was obtained after 5 min, while 15 min were necessary using FeSO(4). The results obtained with Daphnia magna biossays showed that the toxicity decreased from 65 to 5% after 90 min of irradiation in the presence of FeSO(4). However, it increased again to a maximum of 100% after 150 min, what indicates the generation of more toxic intermediates than AMX, reaching 45% after 240 min. However, using FeOx, the inhibition of mobility varied between 100 and 70% during treatment, probably due to the presence of oxalate, which is toxic to the neonates. After 240 min, between 73 and 81% TOC removal was observed. Different pathways of AMX degradation were suggested including the opening of the four-membered β-lactamic ring and further oxidations of the methyl group to aldehyde and/or hydroxylation of the benzoic ring, generating other intermediates after bound cleavage between different atoms and further oxidation to carboxylates such acetate, oxalate and propionate, besides the generation of nitrate and ammonium. SN - 1879-2448 UR - https://www.unboundmedicine.com/medline/citation/21093887/Degradation_of_the_antibiotic_amoxicillin_by_photo_Fenton_process__chemical_and_toxicological_assessment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0043-1354(10)00734-7 DB - PRIME DP - Unbound Medicine ER -