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Release behaviour of clozapine matrix pellets based on percolation theory.
Int J Pharm. 2011 Feb 14; 404(1-2):133-41.IJ

Abstract

The release behaviour of clozapine matrix pellets was studied in order to investigate if it is possible to explain it applying the concepts of percolation theory, previously used in the understanding of the release process of inert and hydrophilic matrix tablets. Thirteen batches of pellets with different proportions of clozapine/microcrystalline cellulose (MCC)/hydroxypropylmethyl cellulose (HPMC) and different clozapine particle size fractions were prepared by extrusion-spheronisation and the release profiles were studied. It has been observed that the distance to the excipient (HPMC) percolation threshold is important to control the release rate. Furthermore, the drug percolation threshold has a big influence in these systems. Batches very close to the drug percolation threshold, show a clear effect of the drug particle size in the release rate. However, this effect is much less evident when there is a bigger distance to the drug percolation threshold, so the release behaviour of clozapine matrix pellets is possible to be explained based on the percolation theory.

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Authors+Show Affiliations

Aguilar-de-Leyva A
Department of Pharmacy and Pharmaceutical Technology, University of Seville, 41012 Seville, Spain. aguilardeleyva@us.es
Sharkawi T
No affiliation info available
Bataille B
No affiliation info available
Baylac G
No affiliation info available
Caraballo I
No affiliation info available

MeSH

Antipsychotic AgentsCalorimetry, Differential ScanningCelluloseChemistry, PharmaceuticalClozapineDosage FormsDrug CarriersDrug CompoundingHydrophobic and Hydrophilic InteractionsHypromellose DerivativesKineticsMethylcelluloseMicroscopy, Electron, ScanningModels, ChemicalParticle SizeRheologySolubilitySurface PropertiesTechnology, Pharmaceutical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21094234

Citation

Aguilar-de-Leyva, Angela, et al. "Release Behaviour of Clozapine Matrix Pellets Based On Percolation Theory." International Journal of Pharmaceutics, vol. 404, no. 1-2, 2011, pp. 133-41.
Aguilar-de-Leyva A, Sharkawi T, Bataille B, et al. Release behaviour of clozapine matrix pellets based on percolation theory. Int J Pharm. 2011;404(1-2):133-41.
Aguilar-de-Leyva, A., Sharkawi, T., Bataille, B., Baylac, G., & Caraballo, I. (2011). Release behaviour of clozapine matrix pellets based on percolation theory. International Journal of Pharmaceutics, 404(1-2), 133-41. https://doi.org/10.1016/j.ijpharm.2010.11.024
Aguilar-de-Leyva A, et al. Release Behaviour of Clozapine Matrix Pellets Based On Percolation Theory. Int J Pharm. 2011 Feb 14;404(1-2):133-41. PubMed PMID: 21094234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release behaviour of clozapine matrix pellets based on percolation theory. AU - Aguilar-de-Leyva,Angela, AU - Sharkawi,Tahmer, AU - Bataille,Bernard, AU - Baylac,Gilles, AU - Caraballo,Isidoro, Y1 - 2010/11/19/ PY - 2010/08/05/received PY - 2010/11/11/revised PY - 2010/11/12/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/4/13/medline SP - 133 EP - 41 JF - International journal of pharmaceutics JO - Int J Pharm VL - 404 IS - 1-2 N2 - The release behaviour of clozapine matrix pellets was studied in order to investigate if it is possible to explain it applying the concepts of percolation theory, previously used in the understanding of the release process of inert and hydrophilic matrix tablets. Thirteen batches of pellets with different proportions of clozapine/microcrystalline cellulose (MCC)/hydroxypropylmethyl cellulose (HPMC) and different clozapine particle size fractions were prepared by extrusion-spheronisation and the release profiles were studied. It has been observed that the distance to the excipient (HPMC) percolation threshold is important to control the release rate. Furthermore, the drug percolation threshold has a big influence in these systems. Batches very close to the drug percolation threshold, show a clear effect of the drug particle size in the release rate. However, this effect is much less evident when there is a bigger distance to the drug percolation threshold, so the release behaviour of clozapine matrix pellets is possible to be explained based on the percolation theory. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/21094234/Release_behaviour_of_clozapine_matrix_pellets_based_on_percolation_theory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(10)00873-2 DB - PRIME DP - Unbound Medicine ER -