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Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan.
Int J Cardiol. 2012 Apr 05; 156(1):41-6.IJ

Abstract

BACKGROUND

Hyperuricemia is thought to be associated with an increased risk of hypertension, impaired renal function and cardiovascular disease. Our aim is to study the prevalence of hyperuricemia and its association with antihypertensive treatment in Taiwanese hypertensive subjects.

METHODS

We recruited 2145 hypertensive subjects from 19 hospitals in four areas of Taiwan. We assessed the prevalence of hyperuricemia and determined the independent risk factors for raised serum uric acid level by multiple logistic regression analyses.

RESULTS

Compared to the general population, hypertensive subjects in Taiwan had a higher prevalence (mean 35% in males, 43% in females) of hyperuricemia; this prevalence being 1.5- and 1.7-fold higher in males and females respectively. Uric acid levels; gout and prevalence of hyperuricemia were found to be highest in the younger age group (20-39 years) and no regional differences were noted. The most important risk factors for hyperuricemia were impaired renal function and diuretic use. Serum uric acid values correlated significantly with four quintiles of serum creatinine (p<0.0001) independent of diuretic use. Diuretic users had a significantly elevated serum uric acid and serum creatinine values than non-users. Among the patients given diuretics, hyperuricemia occurred in 44% of those given thiazides, in 56% of those given loop diuretics, and in 57% of those given aldosterone receptor blockers.

CONCLUSIONS

Diuretic usage and renal function status have a strong impact on the prevalence of hyperuricemia in Taiwanese hypertensive subjects. It is still unclear, however, whether diuretics induce renal failure through elevating serum uric acid levels.

Authors+Show Affiliations

Department of Internal Medicine, Chung Shan Medical University Hospital and School of Medicine, Chung Shan Medical University, Taichung, Taiwan. lcs@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21095025

Citation

Lin, Chung-Sheng, et al. "Prevalence of Hyperuricemia and Its Association With Antihypertensive Treatment in Hypertensive Patients in Taiwan." International Journal of Cardiology, vol. 156, no. 1, 2012, pp. 41-6.
Lin CS, Lee WL, Hung YJ, et al. Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. Int J Cardiol. 2012;156(1):41-6.
Lin, C. S., Lee, W. L., Hung, Y. J., Lee, D. Y., Chen, K. F., Chi, W. C., & Chang, S. C. (2012). Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. International Journal of Cardiology, 156(1), 41-6. https://doi.org/10.1016/j.ijcard.2010.10.033
Lin CS, et al. Prevalence of Hyperuricemia and Its Association With Antihypertensive Treatment in Hypertensive Patients in Taiwan. Int J Cardiol. 2012 Apr 5;156(1):41-6. PubMed PMID: 21095025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan. AU - Lin,Chung-Sheng, AU - Lee,Wen-Ling, AU - Hung,Yi-Jen, AU - Lee,Du-Yi, AU - Chen,Kuei-Feng, AU - Chi,Wen-Che, AU - Chang,Shin-Chieh, Y1 - 2010/11/20/ PY - 2010/05/31/received PY - 2010/10/23/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2012/9/26/medline SP - 41 EP - 6 JF - International journal of cardiology JO - Int J Cardiol VL - 156 IS - 1 N2 - BACKGROUND: Hyperuricemia is thought to be associated with an increased risk of hypertension, impaired renal function and cardiovascular disease. Our aim is to study the prevalence of hyperuricemia and its association with antihypertensive treatment in Taiwanese hypertensive subjects. METHODS: We recruited 2145 hypertensive subjects from 19 hospitals in four areas of Taiwan. We assessed the prevalence of hyperuricemia and determined the independent risk factors for raised serum uric acid level by multiple logistic regression analyses. RESULTS: Compared to the general population, hypertensive subjects in Taiwan had a higher prevalence (mean 35% in males, 43% in females) of hyperuricemia; this prevalence being 1.5- and 1.7-fold higher in males and females respectively. Uric acid levels; gout and prevalence of hyperuricemia were found to be highest in the younger age group (20-39 years) and no regional differences were noted. The most important risk factors for hyperuricemia were impaired renal function and diuretic use. Serum uric acid values correlated significantly with four quintiles of serum creatinine (p<0.0001) independent of diuretic use. Diuretic users had a significantly elevated serum uric acid and serum creatinine values than non-users. Among the patients given diuretics, hyperuricemia occurred in 44% of those given thiazides, in 56% of those given loop diuretics, and in 57% of those given aldosterone receptor blockers. CONCLUSIONS: Diuretic usage and renal function status have a strong impact on the prevalence of hyperuricemia in Taiwanese hypertensive subjects. It is still unclear, however, whether diuretics induce renal failure through elevating serum uric acid levels. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/21095025/Prevalence_of_hyperuricemia_and_its_association_with_antihypertensive_treatment_in_hypertensive_patients_in_Taiwan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(10)00881-8 DB - PRIME DP - Unbound Medicine ER -