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[Effect of cerebral state index as a measure of depth of sedation during target controlled infusion of propofol in patients of different ages].
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Nov; 30(11):2558-61.NF

Abstract

OBJECTIVE

To investigate the effect of cerebral state index (CSI) in measuring the level of sedation during target controlled infusion (TCI) of propofol in patients of different ages.

METHODS

Forty ASA class I-II patients undergoing general anesthesia were divided into group A (65 to 79 years old, n=20) and group B (20 to 55 years, n=20). The sedation level was assessed using OAA/S scale. Anesthesia was induced with TCI of propofol. The target effect-site concentration (CE) was set initially at 0.5 µg/ml followed by increments of 0.5 µg/ml every 5 min until 5 min after the patients lost consciousness and did not respond to pain stimulation (OAA/S=0). OAA/S score was recorded every 20 s, and MAP, HR, SPO(2) and CSI were recorded. Spearman correlation coefficient between OAA/S score and CSI and their prediction probabilities (Pk) were calculated. The values of CE(05), CE(50), CE(95) and CSI(05), CSI(50), CSI(95) at loss of verbal contact (LVC) (OAA/S=2) and loss of consciousness (LOC) (OAA/s≤1) were also calculated.

RESULTS

CSI was well correlated to the sedation depth. The values of CE(50) and CSI50 were 1.3 µg/ml and 69.7 at LVC in group A, and were 1.8 µg/ml and 65.9 at LVC in group B, respectively. The values of CE(50) and CSI(50) were 1.5 µg/ml and 64.3 at LOC in group A, as compared to 2.5 µg/ml and 54.8 at LOC in group B, respectively. When the OAA/S scale was lower than 3, the CSI values in group A were significantly higher than those in group B (P<0.05).

CONCLUSION

CSI can effectively and rapidly distinguish the level of sedation in different age groups. At the same OAA/S scale, the target effect-site concentration in the elderly is obviously lower than that in the young patients, but CSI values were significantly higher in the elderly than in the young patients during TCI of propofol.

Authors+Show Affiliations

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China. xiongyunchuan@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Controlled Clinical Trial
English Abstract
Journal Article

Language

chi

PubMed ID

21097434

Citation

Xiong, Yun-chuan, et al. "[Effect of Cerebral State Index as a Measure of Depth of Sedation During Target Controlled Infusion of Propofol in Patients of Different Ages]." Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, vol. 30, no. 11, 2010, pp. 2558-61.
Xiong YC, Zhong T, Guo QL. [Effect of cerebral state index as a measure of depth of sedation during target controlled infusion of propofol in patients of different ages]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(11):2558-61.
Xiong, Y. C., Zhong, T., & Guo, Q. L. (2010). [Effect of cerebral state index as a measure of depth of sedation during target controlled infusion of propofol in patients of different ages]. Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 30(11), 2558-61.
Xiong YC, Zhong T, Guo QL. [Effect of Cerebral State Index as a Measure of Depth of Sedation During Target Controlled Infusion of Propofol in Patients of Different Ages]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30(11):2558-61. PubMed PMID: 21097434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of cerebral state index as a measure of depth of sedation during target controlled infusion of propofol in patients of different ages]. AU - Xiong,Yun-chuan, AU - Zhong,Tao, AU - Guo,Qu-lian, PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2013/6/19/medline SP - 2558 EP - 61 JF - Nan fang yi ke da xue xue bao = Journal of Southern Medical University JO - Nan Fang Yi Ke Da Xue Xue Bao VL - 30 IS - 11 N2 - OBJECTIVE: To investigate the effect of cerebral state index (CSI) in measuring the level of sedation during target controlled infusion (TCI) of propofol in patients of different ages. METHODS: Forty ASA class I-II patients undergoing general anesthesia were divided into group A (65 to 79 years old, n=20) and group B (20 to 55 years, n=20). The sedation level was assessed using OAA/S scale. Anesthesia was induced with TCI of propofol. The target effect-site concentration (CE) was set initially at 0.5 µg/ml followed by increments of 0.5 µg/ml every 5 min until 5 min after the patients lost consciousness and did not respond to pain stimulation (OAA/S=0). OAA/S score was recorded every 20 s, and MAP, HR, SPO(2) and CSI were recorded. Spearman correlation coefficient between OAA/S score and CSI and their prediction probabilities (Pk) were calculated. The values of CE(05), CE(50), CE(95) and CSI(05), CSI(50), CSI(95) at loss of verbal contact (LVC) (OAA/S=2) and loss of consciousness (LOC) (OAA/s≤1) were also calculated. RESULTS: CSI was well correlated to the sedation depth. The values of CE(50) and CSI50 were 1.3 µg/ml and 69.7 at LVC in group A, and were 1.8 µg/ml and 65.9 at LVC in group B, respectively. The values of CE(50) and CSI(50) were 1.5 µg/ml and 64.3 at LOC in group A, as compared to 2.5 µg/ml and 54.8 at LOC in group B, respectively. When the OAA/S scale was lower than 3, the CSI values in group A were significantly higher than those in group B (P<0.05). CONCLUSION: CSI can effectively and rapidly distinguish the level of sedation in different age groups. At the same OAA/S scale, the target effect-site concentration in the elderly is obviously lower than that in the young patients, but CSI values were significantly higher in the elderly than in the young patients during TCI of propofol. SN - 1673-4254 UR - https://www.unboundmedicine.com/medline/citation/21097434/[Effect_of_cerebral_state_index_as_a_measure_of_depth_of_sedation_during_target_controlled_infusion_of_propofol_in_patients_of_different_ages]_ DB - PRIME DP - Unbound Medicine ER -