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Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance.
Antimicrob Agents Chemother. 2011 Feb; 55(2):921-4.AA

Abstract

In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and acrB, and then mdfA and norE. Our findings suggest acrAB overexpression is an indicator of multidrug resistance.

Authors+Show Affiliations

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030-3411, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21098250

Citation

Swick, Michelle C., et al. "Expression of Multidrug Efflux Pump Genes acrAB-tolC, mdfA, and norE in Escherichia Coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance." Antimicrobial Agents and Chemotherapy, vol. 55, no. 2, 2011, pp. 921-4.
Swick MC, Morgan-Linnell SK, Carlson KM, et al. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrob Agents Chemother. 2011;55(2):921-4.
Swick, M. C., Morgan-Linnell, S. K., Carlson, K. M., & Zechiedrich, L. (2011). Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrobial Agents and Chemotherapy, 55(2), 921-4. https://doi.org/10.1128/AAC.00996-10
Swick MC, et al. Expression of Multidrug Efflux Pump Genes acrAB-tolC, mdfA, and norE in Escherichia Coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance. Antimicrob Agents Chemother. 2011;55(2):921-4. PubMed PMID: 21098250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. AU - Swick,Michelle C, AU - Morgan-Linnell,Sonia K, AU - Carlson,Kimberly M, AU - Zechiedrich,Lynn, Y1 - 2010/11/22/ PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/5/20/medline SP - 921 EP - 4 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 55 IS - 2 N2 - In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux pump transcripts in all fluoroquinolone-susceptible isolates was tolC (highest), then acrA and acrB, and then mdfA and norE. Our findings suggest acrAB overexpression is an indicator of multidrug resistance. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/21098250/Expression_of_multidrug_efflux_pump_genes_acrAB_tolC_mdfA_and_norE_in_Escherichia_coli_clinical_isolates_as_a_function_of_fluoroquinolone_and_multidrug_resistance_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=21098250 DB - PRIME DP - Unbound Medicine ER -