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Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT.
J Ultrasound Med 2010; 29(12):1759-68JU

Abstract

OBJECTIVE

The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD).

METHODS

Cross-sectional measurements of the mean CCA IMT and maximum ICA IMT were made on ultrasound images acquired from the Framingham Offspring cohort (n = 3316; mean age, 58 years; 52.7% women). Linear regression models were used to study the associations of the Framingham risk factors with CCA and ICA IMT. Multivariate logistic regression models and receiver operating characteristic (ROC) curve analysis were used to compare the associations of prevalent CVD with CCA and ICA IMT and determine sensitivity and specificity.

RESULTS

The association between age and the mean CCA IMT corresponded to an increase of 0.007 mm/y; the increase was 0.037 mm/y for the ICA IMT. Framingham risk factors accounted for 28.6% and 27.5% of the variability in the CCA and ICA IMT, respectively. Age and gender contributed 23.5% to the variability of the CCA IMT and 22.5% to that of the ICA IMT, with the next most important factor being systolic blood pressure (1.9%) for the CCA IMT and smoking (1.6%) for the ICA IMT. The CCA IMT and ICA IMT were statistically significant predictors of prevalent CVD, with the ICA IMT having a larger area under the ROC curve (0.756 versus 0.695).

CONCLUSIONS

Associations of risk factors with CCA and ICA IMT are slightly different, and both are independently associated with prevalent CVD. Their value for predicting incident cardiovascular events needs to be compared in outcome studies.

Authors+Show Affiliations

Department of Radiology, Tufts Medical Center, Boston, MA 02111, USA. jpolak@tuftsmedicalcenter.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21098848

Citation

Polak, Joseph F., et al. "Associations of Carotid Artery Intima-media Thickness (IMT) With Risk Factors and Prevalent Cardiovascular Disease: Comparison of Mean Common Carotid Artery IMT With Maximum Internal Carotid Artery IMT." Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, vol. 29, no. 12, 2010, pp. 1759-68.
Polak JF, Pencina MJ, Meisner A, et al. Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. J Ultrasound Med. 2010;29(12):1759-68.
Polak, J. F., Pencina, M. J., Meisner, A., Pencina, K. M., Brown, L. S., Wolf, P. A., & D'Agostino, R. B. (2010). Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, 29(12), pp. 1759-68.
Polak JF, et al. Associations of Carotid Artery Intima-media Thickness (IMT) With Risk Factors and Prevalent Cardiovascular Disease: Comparison of Mean Common Carotid Artery IMT With Maximum Internal Carotid Artery IMT. J Ultrasound Med. 2010;29(12):1759-68. PubMed PMID: 21098848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. AU - Polak,Joseph F, AU - Pencina,Michael J, AU - Meisner,Allison, AU - Pencina,Karol M, AU - Brown,Lisa S, AU - Wolf,Philip A, AU - D'Agostino,Ralph B,Sr PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/4/9/medline SP - 1759 EP - 68 JF - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JO - J Ultrasound Med VL - 29 IS - 12 N2 - OBJECTIVE: The goal of this study was to compare internal carotid artery (ICA) intima-media thickness (IMT) with common carotid artery (CCA) IMT as global markers of cardiovascular disease (CVD). METHODS: Cross-sectional measurements of the mean CCA IMT and maximum ICA IMT were made on ultrasound images acquired from the Framingham Offspring cohort (n = 3316; mean age, 58 years; 52.7% women). Linear regression models were used to study the associations of the Framingham risk factors with CCA and ICA IMT. Multivariate logistic regression models and receiver operating characteristic (ROC) curve analysis were used to compare the associations of prevalent CVD with CCA and ICA IMT and determine sensitivity and specificity. RESULTS: The association between age and the mean CCA IMT corresponded to an increase of 0.007 mm/y; the increase was 0.037 mm/y for the ICA IMT. Framingham risk factors accounted for 28.6% and 27.5% of the variability in the CCA and ICA IMT, respectively. Age and gender contributed 23.5% to the variability of the CCA IMT and 22.5% to that of the ICA IMT, with the next most important factor being systolic blood pressure (1.9%) for the CCA IMT and smoking (1.6%) for the ICA IMT. The CCA IMT and ICA IMT were statistically significant predictors of prevalent CVD, with the ICA IMT having a larger area under the ROC curve (0.756 versus 0.695). CONCLUSIONS: Associations of risk factors with CCA and ICA IMT are slightly different, and both are independently associated with prevalent CVD. Their value for predicting incident cardiovascular events needs to be compared in outcome studies. SN - 1550-9613 UR - https://www.unboundmedicine.com/medline/citation/21098848/Associations_of_carotid_artery_intima_media_thickness__IMT__with_risk_factors_and_prevalent_cardiovascular_disease:_comparison_of_mean_common_carotid_artery_IMT_with_maximum_internal_carotid_artery_IMT_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0278-4297&date=2010&volume=29&issue=12&spage=1759 DB - PRIME DP - Unbound Medicine ER -