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Infectious keratitis treated with corneal crosslinking.
Cornea. 2010 Dec; 29(12):1353-8.C

Abstract

PURPOSE

To describe 7 eyes with severe infectious keratitis treated using collagen crosslinking (CXL) with riboflavin.

MATERIALS AND METHODS

Seven eyes of 6 patients with severe infectious keratitis were treated with corneal crosslinking. Three patients were contact lens users. Symptom duration before CXL ranged between 0 and 7 days. Corneal melting was present in all cases. Photodocumentation of the keratitis was carried out and repeated at follow-up. All but 1 patient received topical antibiotic treatment in addition to the CXL treatment. CXL was conducted according to the standardized protocol for keratoconus.

RESULTS

In all but 1 eye, patients experienced improvement in symptoms within 24 hours. Two patients reported no symptoms whatsoever at this time. Corneal melting was arrested and complete epithelialization was achieved in all cases. In the 2 eyes with hypopyon, this regressed completely within 2 days after the CXL. Follow-up ranged between 1 and 6 months.

DISCUSSION

Our experience based on the above and other cases suggest that CXL could be an effective tool in battling difficult cases of infectious keratitis. This treatment could present many advantages but will need further investigation.

Authors+Show Affiliations

Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden. karim.makdoumi@orebroll.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21102196

Citation

Makdoumi, Karim, et al. "Infectious Keratitis Treated With Corneal Crosslinking." Cornea, vol. 29, no. 12, 2010, pp. 1353-8.
Makdoumi K, Mortensen J, Crafoord S. Infectious keratitis treated with corneal crosslinking. Cornea. 2010;29(12):1353-8.
Makdoumi, K., Mortensen, J., & Crafoord, S. (2010). Infectious keratitis treated with corneal crosslinking. Cornea, 29(12), 1353-8. https://doi.org/10.1097/ICO.0b013e3181d2de91
Makdoumi K, Mortensen J, Crafoord S. Infectious Keratitis Treated With Corneal Crosslinking. Cornea. 2010;29(12):1353-8. PubMed PMID: 21102196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infectious keratitis treated with corneal crosslinking. AU - Makdoumi,Karim, AU - Mortensen,Jes, AU - Crafoord,Sven, PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/2/11/medline SP - 1353 EP - 8 JF - Cornea JO - Cornea VL - 29 IS - 12 N2 - PURPOSE: To describe 7 eyes with severe infectious keratitis treated using collagen crosslinking (CXL) with riboflavin. MATERIALS AND METHODS: Seven eyes of 6 patients with severe infectious keratitis were treated with corneal crosslinking. Three patients were contact lens users. Symptom duration before CXL ranged between 0 and 7 days. Corneal melting was present in all cases. Photodocumentation of the keratitis was carried out and repeated at follow-up. All but 1 patient received topical antibiotic treatment in addition to the CXL treatment. CXL was conducted according to the standardized protocol for keratoconus. RESULTS: In all but 1 eye, patients experienced improvement in symptoms within 24 hours. Two patients reported no symptoms whatsoever at this time. Corneal melting was arrested and complete epithelialization was achieved in all cases. In the 2 eyes with hypopyon, this regressed completely within 2 days after the CXL. Follow-up ranged between 1 and 6 months. DISCUSSION: Our experience based on the above and other cases suggest that CXL could be an effective tool in battling difficult cases of infectious keratitis. This treatment could present many advantages but will need further investigation. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/21102196/Infectious_keratitis_treated_with_corneal_crosslinking_ L2 - https://doi.org/10.1097/ICO.0b013e3181d2de91 DB - PRIME DP - Unbound Medicine ER -