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Complex Interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border.
PLoS Negl Trop Dis. 2010 Nov 16; 4(11):e887.PN

Abstract

BACKGROUND

Deworming is recommended by the WHO in girls and pregnant and lactating women to reduce anaemia in areas where hookworm and anaemia are common. There is conflicting evidence on the harm and the benefits of intestinal geohelminth infections on the incidence and severity of malaria, and consequently on the risks and benefits of deworming in malaria affected populations. We examined the association between geohelminths and malaria in pregnancy on the Thai-Burmese border.

METHODOLOGY

Routine antenatal care (ANC) included active detection of malaria (weekly blood smear) and anaemia (second weekly haematocrit) and systematic reporting of birth outcomes. In 1996 stool samples were collected in cross sectional surveys from women attending the ANCs. This was repeated in 2007 when malaria incidence had reduced considerably. The relationship between geohelminth infection and the progress and outcome of pregnancy was assessed.

PRINCIPAL FINDINGS

Stool sample examination (339 in 1996, 490 in 2007) detected a high prevalence of geohelminths 70% (578/829), including hookworm (42.8% (355)), A. lumbricoides (34.4% (285)) and T.trichuria (31.4% (250)) alone or in combination. A lower proportion of women (829) had mild (21.8% (181)) or severe (0.2% (2)) anaemia, or malaria 22.4% (186) (P.vivax monoinfection 53.3% (101/186)). A. lumbricoides infection was associated with a significantly decreased risk of malaria (any species) (AOR: 0.43, 95% CI: 0.23-0.84) and P.vivax malaria (AOR: 0.29, 95% CI: 0.11-0.79) whereas hookworm infection was associated with an increased risk of malaria (any species) (AOR: 1.66, 95% CI: 1.06-2.60) and anaemia (AOR: 2.41, 95% CI: 1.18-4.93). Hookworm was also associated with low birth weight (AOR: 1.81, 95% CI: 1.02-3.23).

CONCLUSION/SIGNIFICANCE

A. lumbricoides and hookworm appear to have contrary associations with malaria in pregnancy.

Authors+Show Affiliations

Shoklo Malaria Research Unit, Tak, Thailand. machteld@shoklo-unit.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21103367

Citation

Boel, Machteld, et al. "Complex Interactions Between Soil-transmitted Helminths and Malaria in Pregnant Women On the Thai-Burmese Border." PLoS Neglected Tropical Diseases, vol. 4, no. 11, 2010, pp. e887.
Boel M, Carrara VI, Rijken M, et al. Complex Interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border. PLoS Negl Trop Dis. 2010;4(11):e887.
Boel, M., Carrara, V. I., Rijken, M., Proux, S., Nacher, M., Pimanpanarak, M., Paw, M. K., Moo, O., Gay, H., Bailey, W., Singhasivanon, P., White, N. J., Nosten, F., & McGready, R. (2010). Complex Interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border. PLoS Neglected Tropical Diseases, 4(11), e887. https://doi.org/10.1371/journal.pntd.0000887
Boel M, et al. Complex Interactions Between Soil-transmitted Helminths and Malaria in Pregnant Women On the Thai-Burmese Border. PLoS Negl Trop Dis. 2010 Nov 16;4(11):e887. PubMed PMID: 21103367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complex Interactions between soil-transmitted helminths and malaria in pregnant women on the Thai-Burmese border. AU - Boel,Machteld, AU - Carrara,Verena I, AU - Rijken,Marcus, AU - Proux,Stephane, AU - Nacher,Mathieu, AU - Pimanpanarak,Mupawjay, AU - Paw,Moo Koo, AU - Moo,Oh, AU - Gay,Hser, AU - Bailey,Wendi, AU - Singhasivanon,Pratap, AU - White,Nicholas J, AU - Nosten,François, AU - McGready,Rose, Y1 - 2010/11/16/ PY - 2010/05/14/received PY - 2010/10/19/accepted PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/4/13/medline SP - e887 EP - e887 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 4 IS - 11 N2 - BACKGROUND: Deworming is recommended by the WHO in girls and pregnant and lactating women to reduce anaemia in areas where hookworm and anaemia are common. There is conflicting evidence on the harm and the benefits of intestinal geohelminth infections on the incidence and severity of malaria, and consequently on the risks and benefits of deworming in malaria affected populations. We examined the association between geohelminths and malaria in pregnancy on the Thai-Burmese border. METHODOLOGY: Routine antenatal care (ANC) included active detection of malaria (weekly blood smear) and anaemia (second weekly haematocrit) and systematic reporting of birth outcomes. In 1996 stool samples were collected in cross sectional surveys from women attending the ANCs. This was repeated in 2007 when malaria incidence had reduced considerably. The relationship between geohelminth infection and the progress and outcome of pregnancy was assessed. PRINCIPAL FINDINGS: Stool sample examination (339 in 1996, 490 in 2007) detected a high prevalence of geohelminths 70% (578/829), including hookworm (42.8% (355)), A. lumbricoides (34.4% (285)) and T.trichuria (31.4% (250)) alone or in combination. A lower proportion of women (829) had mild (21.8% (181)) or severe (0.2% (2)) anaemia, or malaria 22.4% (186) (P.vivax monoinfection 53.3% (101/186)). A. lumbricoides infection was associated with a significantly decreased risk of malaria (any species) (AOR: 0.43, 95% CI: 0.23-0.84) and P.vivax malaria (AOR: 0.29, 95% CI: 0.11-0.79) whereas hookworm infection was associated with an increased risk of malaria (any species) (AOR: 1.66, 95% CI: 1.06-2.60) and anaemia (AOR: 2.41, 95% CI: 1.18-4.93). Hookworm was also associated with low birth weight (AOR: 1.81, 95% CI: 1.02-3.23). CONCLUSION/SIGNIFICANCE: A. lumbricoides and hookworm appear to have contrary associations with malaria in pregnancy. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/21103367/Complex_Interactions_between_soil_transmitted_helminths_and_malaria_in_pregnant_women_on_the_Thai_Burmese_border_ L2 - https://dx.plos.org/10.1371/journal.pntd.0000887 DB - PRIME DP - Unbound Medicine ER -