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Targeting the cannabinoid system to produce analgesia.
Curr Top Behav Neurosci. 2009; 1:275-87.CT

Abstract

Cannabinoid receptors are present at key sites involved in the relay and modulation of nociceptive responses. The analgesic effects of the cannabinoid CB₁ receptor are well described. The widespread distribution of these receptors in the brain does, however, also explain the side-effects associated with CB₁ receptor agonists. The cannabinoid CB₂ receptor also produces analgesic effects in models of acute, inflammatory and neuropathic pain. The sites and mechanisms of CB₂ receptor-mediated analgesia are described herein. In addition to targeting cannabinoid receptors directly, protection of endocannabinoids (eCBs) from metabolism also produces analgesic effects. Indeed, reports that noxious stimulation elevates levels of eCBs in the spinal cord and brain provide further rationale for this approach. The effects of inhibition of fatty acid amide hydrolase (FAAH) on nociceptive responses in models of inflammatory and neuropathic pain are discussed.

Authors+Show Affiliations

School of Biomedical Sciences, University of Nottingham, Nottingham, UK. Devi.sagar@nottingham.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21104388

Citation

Sagar, Devi Rani, et al. "Targeting the Cannabinoid System to Produce Analgesia." Current Topics in Behavioral Neurosciences, vol. 1, 2009, pp. 275-87.
Sagar DR, Jhaveri M, Chapman V. Targeting the cannabinoid system to produce analgesia. Curr Top Behav Neurosci. 2009;1:275-87.
Sagar, D. R., Jhaveri, M., & Chapman, V. (2009). Targeting the cannabinoid system to produce analgesia. Current Topics in Behavioral Neurosciences, 1, 275-87. https://doi.org/10.1007/978-3-540-88955-7_11
Sagar DR, Jhaveri M, Chapman V. Targeting the Cannabinoid System to Produce Analgesia. Curr Top Behav Neurosci. 2009;1:275-87. PubMed PMID: 21104388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Targeting the cannabinoid system to produce analgesia. AU - Sagar,Devi Rani, AU - Jhaveri,Maulik, AU - Chapman,Victoria, PY - 2010/11/25/entrez PY - 2009/1/1/pubmed PY - 2011/1/5/medline SP - 275 EP - 87 JF - Current topics in behavioral neurosciences JO - Curr Top Behav Neurosci VL - 1 N2 - Cannabinoid receptors are present at key sites involved in the relay and modulation of nociceptive responses. The analgesic effects of the cannabinoid CB₁ receptor are well described. The widespread distribution of these receptors in the brain does, however, also explain the side-effects associated with CB₁ receptor agonists. The cannabinoid CB₂ receptor also produces analgesic effects in models of acute, inflammatory and neuropathic pain. The sites and mechanisms of CB₂ receptor-mediated analgesia are described herein. In addition to targeting cannabinoid receptors directly, protection of endocannabinoids (eCBs) from metabolism also produces analgesic effects. Indeed, reports that noxious stimulation elevates levels of eCBs in the spinal cord and brain provide further rationale for this approach. The effects of inhibition of fatty acid amide hydrolase (FAAH) on nociceptive responses in models of inflammatory and neuropathic pain are discussed. SN - 1866-3370 UR - https://www.unboundmedicine.com/medline/citation/21104388/Targeting_the_cannabinoid_system_to_produce_analgesia_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -