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T3/rT3-ratio is associated with insulin resistance independent of TSH.
Horm Metab Res. 2011 Feb; 43(2):130-4.HM

Abstract

Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and IR we investigated pairs which differed in IR, but were matched by sex, age, body mass index (BMI), and thyroid stimulating hormone (TSH). For this purpose, matched pair analyses were embedded into a cross sectional study group. 22 pairs were matched from either the first or the third tertile of HOMA%S of a cohort of 353 euthyroid subjects with normal glucose metabolism who did not take any medication. The T3/rT3-ratio was compared in the matched pairs. The T3/rT3-ratio was significantly increased in the insulin resistant subjects compared to their insulin sensitive partners (8.78 ± 0.47 vs. 7.33 ± 0.33, p=0.019). Furthermore the T3/rT3-ratio was lower in men compared to women (p for the within-subject effect=0.046) both in the insulin sensitive and the insulin resistant subjects. Here we show that the T3/rT3-ratio, which is supposed to reflect the tissue thyroid hormone metabolism, is significantly increased in insulin resistant subjects. This further supports a link between thyroid function and IR.

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Authors+Show Affiliations

Ruhla S
Department of Endocrinology, Diabetes and Nutrition, Charité-University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany.
Arafat AM
No affiliation info available
Weickert MO
No affiliation info available
Osterhoff M
No affiliation info available
Isken F
No affiliation info available
Spranger J
No affiliation info available
Schöfl C
No affiliation info available
Pfeiffer AF
No affiliation info available
Möhlig M
No affiliation info available

MeSH

AdultBlood GlucoseBody Mass IndexCohort StudiesCross-Sectional StudiesFemaleHumansInsulinInsulin ResistanceMaleMiddle AgedThyrotropinTriiodothyronineTriiodothyronine, Reverse

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21104580

Citation

Ruhla, S, et al. "T3/rT3-ratio Is Associated With Insulin Resistance Independent of TSH." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 43, no. 2, 2011, pp. 130-4.
Ruhla S, Arafat AM, Weickert MO, et al. T3/rT3-ratio is associated with insulin resistance independent of TSH. Horm Metab Res. 2011;43(2):130-4.
Ruhla, S., Arafat, A. M., Weickert, M. O., Osterhoff, M., Isken, F., Spranger, J., Schöfl, C., Pfeiffer, A. F., & Möhlig, M. (2011). T3/rT3-ratio is associated with insulin resistance independent of TSH. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 43(2), 130-4. https://doi.org/10.1055/s-0030-1267997
Ruhla S, et al. T3/rT3-ratio Is Associated With Insulin Resistance Independent of TSH. Horm Metab Res. 2011;43(2):130-4. PubMed PMID: 21104580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T3/rT3-ratio is associated with insulin resistance independent of TSH. AU - Ruhla,S, AU - Arafat,A M, AU - Weickert,M O, AU - Osterhoff,M, AU - Isken,F, AU - Spranger,J, AU - Schöfl,C, AU - Pfeiffer,A F H, AU - Möhlig,M, Y1 - 2010/11/22/ PY - 2010/11/25/entrez PY - 2010/11/26/pubmed PY - 2011/5/25/medline SP - 130 EP - 4 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 43 IS - 2 N2 - Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and IR we investigated pairs which differed in IR, but were matched by sex, age, body mass index (BMI), and thyroid stimulating hormone (TSH). For this purpose, matched pair analyses were embedded into a cross sectional study group. 22 pairs were matched from either the first or the third tertile of HOMA%S of a cohort of 353 euthyroid subjects with normal glucose metabolism who did not take any medication. The T3/rT3-ratio was compared in the matched pairs. The T3/rT3-ratio was significantly increased in the insulin resistant subjects compared to their insulin sensitive partners (8.78 ± 0.47 vs. 7.33 ± 0.33, p=0.019). Furthermore the T3/rT3-ratio was lower in men compared to women (p for the within-subject effect=0.046) both in the insulin sensitive and the insulin resistant subjects. Here we show that the T3/rT3-ratio, which is supposed to reflect the tissue thyroid hormone metabolism, is significantly increased in insulin resistant subjects. This further supports a link between thyroid function and IR. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/21104580/T3/rT3_ratio_is_associated_with_insulin_resistance_independent_of_TSH_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1267997 DB - PRIME DP - Unbound Medicine ER -