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Apolipoprotein E and central nervous system disorders: reviews of clinical findings.
Psychiatry Clin Neurosci 2010; 64(6):592-607PC

Abstract

Dementia is a major health problem in developed countries with over 25 million people affected worldwide and probably over 75 million people at risk during the next 20 years. Alzheimer's disease (AD) is the most frequent cause of dementia (50-70%), followed by vascular dementia (30-40%), and mixed dementia (15-20%). AD pathogenesis is still to be elucidated but it is believed to be the complex interaction between genetic and environmental factors in later life. Three causative genes for familial AD have been identified: amyloid precursor protein, presenilin-1, and presenilin-2. There are 150 genes involved with increased neuronal vulnerability to premature death in the AD brain. Among these susceptibility genes, the apolipoprotein E (ApoE) gene is the most prevalent as a risk for AD pathogenic process in which complex interactions between genetic and environmental factors are involved, leading to a cascade of pathogenic events converging in final pathways to premature neuronal death. Some of these mechanisms are common to several neurodegenerative disorders that differ depending upon the genes affected and the involvement of environmental conditions. ApoE is a key lipoprotein in lipid and cholesterol metabolism and it is also the major risk gene for AD and many other central nervous system disorders. The pathogenic role of ApoE-4 is still to be clarified; however, diverse evidence suggests that ApoE may play pleiotropic functions in dementia and central nervous system disorders.

Authors+Show Affiliations

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan. mtakeda@psy.med.osaka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21105952

Citation

Takeda, Masatoshi, et al. "Apolipoprotein E and Central Nervous System Disorders: Reviews of Clinical Findings." Psychiatry and Clinical Neurosciences, vol. 64, no. 6, 2010, pp. 592-607.
Takeda M, Martínez R, Kudo T, et al. Apolipoprotein E and central nervous system disorders: reviews of clinical findings. Psychiatry Clin Neurosci. 2010;64(6):592-607.
Takeda, M., Martínez, R., Kudo, T., Tanaka, T., Okochi, M., Tagami, S., ... Cacabelos, R. (2010). Apolipoprotein E and central nervous system disorders: reviews of clinical findings. Psychiatry and Clinical Neurosciences, 64(6), pp. 592-607. doi:10.1111/j.1440-1819.2010.02148.x.
Takeda M, et al. Apolipoprotein E and Central Nervous System Disorders: Reviews of Clinical Findings. Psychiatry Clin Neurosci. 2010;64(6):592-607. PubMed PMID: 21105952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E and central nervous system disorders: reviews of clinical findings. AU - Takeda,Masatoshi, AU - Martínez,Rocío, AU - Kudo,Takashi, AU - Tanaka,Toshihisa, AU - Okochi,Masayasu, AU - Tagami,Shinji, AU - Morihara,Takashi, AU - Hashimoto,Ryota, AU - Cacabelos,Ramón, PY - 2010/11/26/entrez PY - 2010/11/26/pubmed PY - 2011/4/8/medline SP - 592 EP - 607 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin. Neurosci. VL - 64 IS - 6 N2 - Dementia is a major health problem in developed countries with over 25 million people affected worldwide and probably over 75 million people at risk during the next 20 years. Alzheimer's disease (AD) is the most frequent cause of dementia (50-70%), followed by vascular dementia (30-40%), and mixed dementia (15-20%). AD pathogenesis is still to be elucidated but it is believed to be the complex interaction between genetic and environmental factors in later life. Three causative genes for familial AD have been identified: amyloid precursor protein, presenilin-1, and presenilin-2. There are 150 genes involved with increased neuronal vulnerability to premature death in the AD brain. Among these susceptibility genes, the apolipoprotein E (ApoE) gene is the most prevalent as a risk for AD pathogenic process in which complex interactions between genetic and environmental factors are involved, leading to a cascade of pathogenic events converging in final pathways to premature neuronal death. Some of these mechanisms are common to several neurodegenerative disorders that differ depending upon the genes affected and the involvement of environmental conditions. ApoE is a key lipoprotein in lipid and cholesterol metabolism and it is also the major risk gene for AD and many other central nervous system disorders. The pathogenic role of ApoE-4 is still to be clarified; however, diverse evidence suggests that ApoE may play pleiotropic functions in dementia and central nervous system disorders. SN - 1440-1819 UR - https://www.unboundmedicine.com/medline/citation/21105952/Apolipoprotein_E_and_central_nervous_system_disorders:_reviews_of_clinical_findings_ L2 - https://doi.org/10.1111/j.1440-1819.2010.02148.x DB - PRIME DP - Unbound Medicine ER -