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Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.
Am J Clin Nutr. 2011 Jan; 93(1):211-9.AJ

Abstract

BACKGROUND

Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Δ⁵-desaturase and Δ⁶-desaturase. Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic acid (AA) amounts. Associations with docosahexaenoic acid (DHA), which is considered particularly important for brain and retina development, are hardly existent.

OBJECTIVE

We explored the relation between FADS gene cluster polymorphisms and red blood cell (RBC) FA amounts in > 4000 pregnant women participating in the Avon Longitudinal Study of Parents and Children.

DESIGN

Linear regression analysis of 17 single nucleotide polymorphisms (SNPs) in the FADS gene cluster was conducted with RBC phospholipid FAs from 6711 samples from 4457 women obtained throughout pregnancy (mean ± SD gestational age: 26.8 ± 8.2 wk).

RESULTS

Independent of dietary effects, the minor alleles were consistently positively associated with precursor FAs and negatively associated with LC-PUFAs and product:substrate ratios of the n-6 (AA:linoleic acid ratio) and n-3 (eicosapentaenoic acid:α-linolenic acid ratio) pathways. In contrast to previous studies, we also showed significant inverse associations with DHA. Similar but weaker associations were shown for the FADS3 SNP rs174455.

CONCLUSIONS

FADS genotypes influence DHA amounts in maternal RBC phospholipids and might affect the child's DHA supply during pregnancy. It is highly likely that a gene product of FADS3 has a desaturating activity.

Authors+Show Affiliations

Department of Pediatrics, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany. office.koletzko@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21106917

Citation

Koletzko, Berthold, et al. "Genetic Variants of the Fatty Acid Desaturase Gene Cluster Predict Amounts of Red Blood Cell Docosahexaenoic and Other Polyunsaturated Fatty Acids in Pregnant Women: Findings From the Avon Longitudinal Study of Parents and Children." The American Journal of Clinical Nutrition, vol. 93, no. 1, 2011, pp. 211-9.
Koletzko B, Lattka E, Zeilinger S, et al. Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2011;93(1):211-9.
Koletzko, B., Lattka, E., Zeilinger, S., Illig, T., & Steer, C. (2011). Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. The American Journal of Clinical Nutrition, 93(1), 211-9. https://doi.org/10.3945/ajcn.110.006189
Koletzko B, et al. Genetic Variants of the Fatty Acid Desaturase Gene Cluster Predict Amounts of Red Blood Cell Docosahexaenoic and Other Polyunsaturated Fatty Acids in Pregnant Women: Findings From the Avon Longitudinal Study of Parents and Children. Am J Clin Nutr. 2011;93(1):211-9. PubMed PMID: 21106917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children. AU - Koletzko,Berthold, AU - Lattka,Eva, AU - Zeilinger,Sonja, AU - Illig,Thomas, AU - Steer,Colin, Y1 - 2010/11/24/ PY - 2010/11/26/entrez PY - 2010/11/26/pubmed PY - 2011/1/29/medline SP - 211 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 93 IS - 1 N2 - BACKGROUND: Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Δ⁵-desaturase and Δ⁶-desaturase. Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic acid (AA) amounts. Associations with docosahexaenoic acid (DHA), which is considered particularly important for brain and retina development, are hardly existent. OBJECTIVE: We explored the relation between FADS gene cluster polymorphisms and red blood cell (RBC) FA amounts in > 4000 pregnant women participating in the Avon Longitudinal Study of Parents and Children. DESIGN: Linear regression analysis of 17 single nucleotide polymorphisms (SNPs) in the FADS gene cluster was conducted with RBC phospholipid FAs from 6711 samples from 4457 women obtained throughout pregnancy (mean ± SD gestational age: 26.8 ± 8.2 wk). RESULTS: Independent of dietary effects, the minor alleles were consistently positively associated with precursor FAs and negatively associated with LC-PUFAs and product:substrate ratios of the n-6 (AA:linoleic acid ratio) and n-3 (eicosapentaenoic acid:α-linolenic acid ratio) pathways. In contrast to previous studies, we also showed significant inverse associations with DHA. Similar but weaker associations were shown for the FADS3 SNP rs174455. CONCLUSIONS: FADS genotypes influence DHA amounts in maternal RBC phospholipids and might affect the child's DHA supply during pregnancy. It is highly likely that a gene product of FADS3 has a desaturating activity. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/21106917/Genetic_variants_of_the_fatty_acid_desaturase_gene_cluster_predict_amounts_of_red_blood_cell_docosahexaenoic_and_other_polyunsaturated_fatty_acids_in_pregnant_women:_findings_from_the_Avon_Longitudinal_Study_of_Parents_and_Children_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.110.006189 DB - PRIME DP - Unbound Medicine ER -