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Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro.
J Mater Sci Mater Med. 2011 Jan; 22(1):115-23.JM

Abstract

Hydrogels are extensively studied as carrier matrices for the controlled release of bioactive molecules. The aim of this study was to design gelatin-based hydrogels crosslinked with genipin and study the impact of crosslinking temperature (5, 15 or 25°C) on gel strength, microstructure, cytocompatibility, swelling and drug release. Gels crosslinked at 25°C exhibited the highest Flory-Rehner crosslink density, lowest swelling ratio and the slowest release of indomethacin (Idn, model anti-inflammatory drug). Diffusional exponents (n) indicated non-Fickian swelling kinetics while drug transport was anomalous. Hydrogel biocompatibility, in vitro cell viability, cell cycle experiments with AH-927 and HaCaT cell lines indicated normal cell proliferation without any effect on cell cycle. Overall, these results substantiated the use of genipin-crosslinked hydrogels as a viable carrier matrix for drug release applications.

Authors+Show Affiliations

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21107660

Citation

Thakur, Goutam, et al. "Crosslinking of Gelatin-based Drug Carriers By Genipin Induces Changes in Drug Kinetic Profiles in Vitro." Journal of Materials Science. Materials in Medicine, vol. 22, no. 1, 2011, pp. 115-23.
Thakur G, Mitra A, Rousseau D, et al. Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro. J Mater Sci Mater Med. 2011;22(1):115-23.
Thakur, G., Mitra, A., Rousseau, D., Basak, A., Sarkar, S., & Pal, K. (2011). Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro. Journal of Materials Science. Materials in Medicine, 22(1), 115-23. https://doi.org/10.1007/s10856-010-4185-3
Thakur G, et al. Crosslinking of Gelatin-based Drug Carriers By Genipin Induces Changes in Drug Kinetic Profiles in Vitro. J Mater Sci Mater Med. 2011;22(1):115-23. PubMed PMID: 21107660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro. AU - Thakur,Goutam, AU - Mitra,Analava, AU - Rousseau,Dérick, AU - Basak,Amit, AU - Sarkar,Siddik, AU - Pal,Kunal, Y1 - 2010/11/25/ PY - 2010/09/06/received PY - 2010/11/07/accepted PY - 2010/11/26/entrez PY - 2010/11/26/pubmed PY - 2011/5/13/medline SP - 115 EP - 23 JF - Journal of materials science. Materials in medicine JO - J Mater Sci Mater Med VL - 22 IS - 1 N2 - Hydrogels are extensively studied as carrier matrices for the controlled release of bioactive molecules. The aim of this study was to design gelatin-based hydrogels crosslinked with genipin and study the impact of crosslinking temperature (5, 15 or 25°C) on gel strength, microstructure, cytocompatibility, swelling and drug release. Gels crosslinked at 25°C exhibited the highest Flory-Rehner crosslink density, lowest swelling ratio and the slowest release of indomethacin (Idn, model anti-inflammatory drug). Diffusional exponents (n) indicated non-Fickian swelling kinetics while drug transport was anomalous. Hydrogel biocompatibility, in vitro cell viability, cell cycle experiments with AH-927 and HaCaT cell lines indicated normal cell proliferation without any effect on cell cycle. Overall, these results substantiated the use of genipin-crosslinked hydrogels as a viable carrier matrix for drug release applications. SN - 1573-4838 UR - https://www.unboundmedicine.com/medline/citation/21107660/Crosslinking_of_gelatin_based_drug_carriers_by_genipin_induces_changes_in_drug_kinetic_profiles_in_vitro_ L2 - https://doi.org/10.1007/s10856-010-4185-3 DB - PRIME DP - Unbound Medicine ER -