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Ductal carcinoma in situ of the breast: influence of age on diagnostic, therapeutic, and prognostic features. Retrospective study of 812 patients.
Ann Surg Oncol. 2011 May; 18(5):1372-9.AS

Abstract

BACKGROUND

The objective of this retrospective study was to identify prognostic, diagnostic, and therapeutic disparities between younger (≤ 40 years) and older (> 40 years) women with ductal carcinoma in situ (DCIS) of the breast.

METHODS

From 1971 to 2001, all patients treated for DCIS at Institut Bergonié were included in our analyses. Follow-up data was collected over 10 years. We used univariate and multivariate analyses to investigate patient-, disease-, and treatment-related factors predictive of diagnostic, histological, therapeutic, and prognostic DCIS criteria.

RESULTS

A total of 812 patients were eligible including 731 women aged >40 years and 81 women ≤40 years. Younger women with DCIS were more likely to receive a mastectomy and less likely to receive radiotherapy. Young age and initial surgical treatment (lumpectomy and especially nonfree margins) were revealed as predictive of recurrence in multivariate analyses.

CONCLUSIONS

Young age represents a recurrence risk independent of histological and clinical characteristics of the tumor. Initial treatment, especially for nonfree margins, is also a predictive factor. Appropriate initial surgery with particularly wide margins appears essential for the treatment of young women with DCIS.

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Authors+Show Affiliations

Tunon-de-Lara C
Department of Surgery, Institut Bergonié, Bordeaux Cedex, France. tunon@bergonie.org
André G
No affiliation info available
Macgrogan G
No affiliation info available
Dilhuydy JM
No affiliation info available
Bussières JE
No affiliation info available
Debled M
No affiliation info available
Mauriac L
No affiliation info available
Brouste V
No affiliation info available
de Mascarel I
No affiliation info available
Avril A
No affiliation info available

MeSH

AdultAge FactorsAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularFemaleFollow-Up StudiesHumansMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsSurvival Rate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21108045

Citation

Tunon-de-Lara, Christine, et al. "Ductal Carcinoma in Situ of the Breast: Influence of Age On Diagnostic, Therapeutic, and Prognostic Features. Retrospective Study of 812 Patients." Annals of Surgical Oncology, vol. 18, no. 5, 2011, pp. 1372-9.
Tunon-de-Lara C, André G, Macgrogan G, et al. Ductal carcinoma in situ of the breast: influence of age on diagnostic, therapeutic, and prognostic features. Retrospective study of 812 patients. Ann Surg Oncol. 2011;18(5):1372-9.
Tunon-de-Lara, C., André, G., Macgrogan, G., Dilhuydy, J. M., Bussières, J. E., Debled, M., Mauriac, L., Brouste, V., de Mascarel, I., & Avril, A. (2011). Ductal carcinoma in situ of the breast: influence of age on diagnostic, therapeutic, and prognostic features. Retrospective study of 812 patients. Annals of Surgical Oncology, 18(5), 1372-9. https://doi.org/10.1245/s10434-010-1441-1
Tunon-de-Lara C, et al. Ductal Carcinoma in Situ of the Breast: Influence of Age On Diagnostic, Therapeutic, and Prognostic Features. Retrospective Study of 812 Patients. Ann Surg Oncol. 2011;18(5):1372-9. PubMed PMID: 21108045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ductal carcinoma in situ of the breast: influence of age on diagnostic, therapeutic, and prognostic features. Retrospective study of 812 patients. AU - Tunon-de-Lara,Christine, AU - André,Gwenaëlle, AU - Macgrogan,Gaétan, AU - Dilhuydy,Jean-Marie, AU - Bussières,Jean-Emmanuel, AU - Debled,Marc, AU - Mauriac,Louis, AU - Brouste,Véronique, AU - de Mascarel,Isabelle, AU - Avril,Antoine, Y1 - 2010/11/25/ PY - 2010/07/01/received PY - 2010/11/26/entrez PY - 2010/11/26/pubmed PY - 2011/8/31/medline SP - 1372 EP - 9 JF - Annals of surgical oncology JO - Ann Surg Oncol VL - 18 IS - 5 N2 - BACKGROUND: The objective of this retrospective study was to identify prognostic, diagnostic, and therapeutic disparities between younger (≤ 40 years) and older (> 40 years) women with ductal carcinoma in situ (DCIS) of the breast. METHODS: From 1971 to 2001, all patients treated for DCIS at Institut Bergonié were included in our analyses. Follow-up data was collected over 10 years. We used univariate and multivariate analyses to investigate patient-, disease-, and treatment-related factors predictive of diagnostic, histological, therapeutic, and prognostic DCIS criteria. RESULTS: A total of 812 patients were eligible including 731 women aged >40 years and 81 women ≤40 years. Younger women with DCIS were more likely to receive a mastectomy and less likely to receive radiotherapy. Young age and initial surgical treatment (lumpectomy and especially nonfree margins) were revealed as predictive of recurrence in multivariate analyses. CONCLUSIONS: Young age represents a recurrence risk independent of histological and clinical characteristics of the tumor. Initial treatment, especially for nonfree margins, is also a predictive factor. Appropriate initial surgery with particularly wide margins appears essential for the treatment of young women with DCIS. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/21108045/Ductal_carcinoma_in_situ_of_the_breast:_influence_of_age_on_diagnostic_therapeutic_and_prognostic_features__Retrospective_study_of_812_patients_ L2 - https://dx.doi.org/10.1245/s10434-010-1441-1 DB - PRIME DP - Unbound Medicine ER -