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Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media.
Biosens Bioelectron. 2011 Jan 15; 26(5):2454-9.BB

Abstract

Zwitterionic hydrogels based on poly(carboxybetaine) methacrylate (polyCBMA) were developed to protect implantable electrochemical glucose biosensors from biofouling in complex media. To enhance the linearity and sensitivity of the sensing profile, both physical and chemical adsorption methods were developed. Results show that glucose sensors coated with polyCBMA hydrogels via the chemical method achieve very high sensitivity and good linearity in response to glucose in PBS, 10%, 50%, and 100% human blood serum. Essentially identical glucose signals were observed even after prolonged exposure to blood samples for over 12 days. The excellent performance of polyCBMA hydrogel coating offers great promise for designing biocompatible implantable glucose biosensors in biological medium.

Authors+Show Affiliations

Department of Chemical Engineering, University of Washington, Seattle, WA 98195, United States.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21111598

Citation

Yang, Wei, et al. "Zwitterionic Poly(carboxybetaine) Hydrogels for Glucose Biosensors in Complex Media." Biosensors & Bioelectronics, vol. 26, no. 5, 2011, pp. 2454-9.
Yang W, Xue H, Carr LR, et al. Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media. Biosens Bioelectron. 2011;26(5):2454-9.
Yang, W., Xue, H., Carr, L. R., Wang, J., & Jiang, S. (2011). Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media. Biosensors & Bioelectronics, 26(5), 2454-9. https://doi.org/10.1016/j.bios.2010.10.031
Yang W, et al. Zwitterionic Poly(carboxybetaine) Hydrogels for Glucose Biosensors in Complex Media. Biosens Bioelectron. 2011 Jan 15;26(5):2454-9. PubMed PMID: 21111598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zwitterionic poly(carboxybetaine) hydrogels for glucose biosensors in complex media. AU - Yang,Wei, AU - Xue,Hong, AU - Carr,Louisa R, AU - Wang,Joseph, AU - Jiang,Shaoyi, Y1 - 2010/10/27/ PY - 2010/08/06/received PY - 2010/10/07/revised PY - 2010/10/19/accepted PY - 2010/11/30/entrez PY - 2010/11/30/pubmed PY - 2011/4/16/medline SP - 2454 EP - 9 JF - Biosensors & bioelectronics JO - Biosens Bioelectron VL - 26 IS - 5 N2 - Zwitterionic hydrogels based on poly(carboxybetaine) methacrylate (polyCBMA) were developed to protect implantable electrochemical glucose biosensors from biofouling in complex media. To enhance the linearity and sensitivity of the sensing profile, both physical and chemical adsorption methods were developed. Results show that glucose sensors coated with polyCBMA hydrogels via the chemical method achieve very high sensitivity and good linearity in response to glucose in PBS, 10%, 50%, and 100% human blood serum. Essentially identical glucose signals were observed even after prolonged exposure to blood samples for over 12 days. The excellent performance of polyCBMA hydrogel coating offers great promise for designing biocompatible implantable glucose biosensors in biological medium. SN - 1873-4235 UR - https://www.unboundmedicine.com/medline/citation/21111598/Zwitterionic_poly_carboxybetaine__hydrogels_for_glucose_biosensors_in_complex_media_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0956-5663(10)00716-5 DB - PRIME DP - Unbound Medicine ER -