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Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice.
J Ethnopharmacol. 2011 Feb 16; 133(3):1077-84.JE

Abstract

AIM OF THIS STUDY

Gochnatia polymorpha ssp. floccosa (Asteraceae), popularly known as "cambará", is well recognized in Brazilian traditional medicine to treat the respiratory tract inflammatory diseases and rheumatism. However, no scientific data have been published to support this ethnopharmacological use. This work aimed to evaluate the anti-inflammatory action of its ethanol (EEGP) extract, ethyl acetate (EA), dichloromethane (DCM), petroleum ether (PE) butanolic (BT) fractions, and the isolated compounds bauerenyl acetate (GPC1) and 11,13-dihydrozaluzanin C (GPC2).

MATERIALS AND METHODS

The anti-inflammatory activities were evaluated in mice subjected to paw oedema and carrageenan-induced air pouch inflammation models.

RESULTS

The oral administration of EEGP (30, 100 and 300 mg/kg), DCM (50 mg/kg), BT (20 mg/kg) and GPC2 (10 and 30 mg/kg), but not EP and EA fractions (both at 30 mg/kg) and GPC1 (1 and 10 mg/kg), significantly inhibited the paw oedema induced by carrageenan (41±13, 39±5 and 60±10% for EEGP at the three doses, respectively; 44,47±12.8 and 70.19±11.52% for DCM and BT, respectively; and 29.52±4.8 and 31.67±5.4%, for 11,13-dihydrozaluzanin C at 10 and 30mg/kg, respectively) compared to control group. The oral administration of EEGP (30, 100 and 300 mg/kg) inhibited the carrageenan-induced leukocyte migration in the air pouch model (37.2±12.5, 62.6±5.0 and 54.3±6.8%, respectively), as well as protein extravasation (47.9±12.5, 51.7±15.2 and 60.9±13.7%, respectively) compared to control group. In a similar way, DCM (50 mg/kg) or GPC2 (10 mg/kg), but not BT (20 mg/kg) given by oral route inhibited leukocyte infiltration into the pouch (29.5±10.6 and 54.4±21.8%, respectively). Also DCM and GPC2 significantly reduced the protein levels in the supernatants (52.4±15.0 and 51.83±16.9%, respectively).

CONCLUSION

The results suggest that EEGP, and BT and DCM fractions from G. polymorpha possess anti-inflammatory activity and probably the compound 11,13-dihydrozaluzanin C was responsible, at least in part, for this action.

Authors+Show Affiliations

Departamento de Farmacologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21111798

Citation

Piornedo, Rene dos Reis, et al. "Anti-inflammatory Activity of Extracts and 11,13-dihydrozaluzanin C From Gochnatia Polymorpha Ssp. Floccosa Trunk Bark in Mice." Journal of Ethnopharmacology, vol. 133, no. 3, 2011, pp. 1077-84.
Piornedo Rdos R, de Souza P, Stefanello MÉ, et al. Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. J Ethnopharmacol. 2011;133(3):1077-84.
Piornedo, R. d. o. s. . R., de Souza, P., Stefanello, M. É., Strapasson, R. L., Zampronio, A. R., & Kassuya, C. A. (2011). Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. Journal of Ethnopharmacology, 133(3), 1077-84. https://doi.org/10.1016/j.jep.2010.11.040
Piornedo Rdos R, et al. Anti-inflammatory Activity of Extracts and 11,13-dihydrozaluzanin C From Gochnatia Polymorpha Ssp. Floccosa Trunk Bark in Mice. J Ethnopharmacol. 2011 Feb 16;133(3):1077-84. PubMed PMID: 21111798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activity of extracts and 11,13-dihydrozaluzanin C from Gochnatia polymorpha ssp. floccosa trunk bark in mice. AU - Piornedo,Rene dos Reis, AU - de Souza,Priscila, AU - Stefanello,Maria Élida Alves, AU - Strapasson,Regiane Lauriano Batista, AU - Zampronio,Aleksander Roberto, AU - Kassuya,Candida Aparecida Leite, Y1 - 2010/11/25/ PY - 2010/08/29/received PY - 2010/11/17/revised PY - 2010/11/17/accepted PY - 2010/11/30/entrez PY - 2010/11/30/pubmed PY - 2011/6/7/medline SP - 1077 EP - 84 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 133 IS - 3 N2 - AIM OF THIS STUDY: Gochnatia polymorpha ssp. floccosa (Asteraceae), popularly known as "cambará", is well recognized in Brazilian traditional medicine to treat the respiratory tract inflammatory diseases and rheumatism. However, no scientific data have been published to support this ethnopharmacological use. This work aimed to evaluate the anti-inflammatory action of its ethanol (EEGP) extract, ethyl acetate (EA), dichloromethane (DCM), petroleum ether (PE) butanolic (BT) fractions, and the isolated compounds bauerenyl acetate (GPC1) and 11,13-dihydrozaluzanin C (GPC2). MATERIALS AND METHODS: The anti-inflammatory activities were evaluated in mice subjected to paw oedema and carrageenan-induced air pouch inflammation models. RESULTS: The oral administration of EEGP (30, 100 and 300 mg/kg), DCM (50 mg/kg), BT (20 mg/kg) and GPC2 (10 and 30 mg/kg), but not EP and EA fractions (both at 30 mg/kg) and GPC1 (1 and 10 mg/kg), significantly inhibited the paw oedema induced by carrageenan (41±13, 39±5 and 60±10% for EEGP at the three doses, respectively; 44,47±12.8 and 70.19±11.52% for DCM and BT, respectively; and 29.52±4.8 and 31.67±5.4%, for 11,13-dihydrozaluzanin C at 10 and 30mg/kg, respectively) compared to control group. The oral administration of EEGP (30, 100 and 300 mg/kg) inhibited the carrageenan-induced leukocyte migration in the air pouch model (37.2±12.5, 62.6±5.0 and 54.3±6.8%, respectively), as well as protein extravasation (47.9±12.5, 51.7±15.2 and 60.9±13.7%, respectively) compared to control group. In a similar way, DCM (50 mg/kg) or GPC2 (10 mg/kg), but not BT (20 mg/kg) given by oral route inhibited leukocyte infiltration into the pouch (29.5±10.6 and 54.4±21.8%, respectively). Also DCM and GPC2 significantly reduced the protein levels in the supernatants (52.4±15.0 and 51.83±16.9%, respectively). CONCLUSION: The results suggest that EEGP, and BT and DCM fractions from G. polymorpha possess anti-inflammatory activity and probably the compound 11,13-dihydrozaluzanin C was responsible, at least in part, for this action. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/21111798/Anti_inflammatory_activity_of_extracts_and_1113_dihydrozaluzanin_C_from_Gochnatia_polymorpha_ssp__floccosa_trunk_bark_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00825-1 DB - PRIME DP - Unbound Medicine ER -