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The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration.
Phytomedicine 2011; 18(7):575-8P

Abstract

Crocetin, a unique carotenoid with a short carbon chain length, is an active compound of saffron and Gardenia jasminoides Ellis used as traditional herbal medicine. The present study was undertaken to investigate the pharmacokinetic profiles of crocetin in healthy adult subjects. The study was conducted as an open-label, single dose escalation with 10 Filipino volunteers (5 men and 5 women). The subjects received a single dose of crocetin at three doses (7.5, 15 and 22.5 mg) in one week interval. Blood samples were collected from the brachial vein before and at 1, 2, 4, 6, 8, 10 and 24 h after administration. Plasma concentrations of crocetin were determined by high-performance liquid chromatography (HPLC). Crocetin was rapidly absorbed and detected within an hour of administration with a mean time to reach maximum concentration (T(max)) of crocetin ranging from 4.0 to 4.8 h. The mean values of C(max) and AUC(0-24h) ranged from 100.9 to 279.7 ng/ml and 556.5 to 1720.8 ng. h/ml respectively. C(max) and AUC values increased with dose proportional manner. Crocetin was eliminated from human plasma with a mean elimination half life (T(½) of 6.1 to 7.5 h. In summary, there were no serious adverse events up to 22.5 mg dose of crocetin while crocetin was found to be absorbed more quickly than the other carotenoids such as β-carotene, lutein and lycopene.

Authors+Show Affiliations

Riken Vitamin Co., Ltd., 5-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan. nao_umigai@rike-vita.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21112749

Citation

Umigai, N, et al. "The Pharmacokinetic Profile of Crocetin in Healthy Adult Human Volunteers After a Single Oral Administration." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 18, no. 7, 2011, pp. 575-8.
Umigai N, Murakami K, Ulit MV, et al. The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration. Phytomedicine. 2011;18(7):575-8.
Umigai, N., Murakami, K., Ulit, M. V., Antonio, L. S., Shirotori, M., Morikawa, H., & Nakano, T. (2011). The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 18(7), pp. 575-8. doi:10.1016/j.phymed.2010.10.019.
Umigai N, et al. The Pharmacokinetic Profile of Crocetin in Healthy Adult Human Volunteers After a Single Oral Administration. Phytomedicine. 2011 May 15;18(7):575-8. PubMed PMID: 21112749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration. AU - Umigai,N, AU - Murakami,K, AU - Ulit,M V, AU - Antonio,L S, AU - Shirotori,M, AU - Morikawa,H, AU - Nakano,T, Y1 - 2010/11/26/ PY - 2010/05/19/received PY - 2010/09/10/revised PY - 2010/10/19/accepted PY - 2010/11/30/entrez PY - 2010/11/30/pubmed PY - 2012/9/7/medline SP - 575 EP - 8 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 18 IS - 7 N2 - Crocetin, a unique carotenoid with a short carbon chain length, is an active compound of saffron and Gardenia jasminoides Ellis used as traditional herbal medicine. The present study was undertaken to investigate the pharmacokinetic profiles of crocetin in healthy adult subjects. The study was conducted as an open-label, single dose escalation with 10 Filipino volunteers (5 men and 5 women). The subjects received a single dose of crocetin at three doses (7.5, 15 and 22.5 mg) in one week interval. Blood samples were collected from the brachial vein before and at 1, 2, 4, 6, 8, 10 and 24 h after administration. Plasma concentrations of crocetin were determined by high-performance liquid chromatography (HPLC). Crocetin was rapidly absorbed and detected within an hour of administration with a mean time to reach maximum concentration (T(max)) of crocetin ranging from 4.0 to 4.8 h. The mean values of C(max) and AUC(0-24h) ranged from 100.9 to 279.7 ng/ml and 556.5 to 1720.8 ng. h/ml respectively. C(max) and AUC values increased with dose proportional manner. Crocetin was eliminated from human plasma with a mean elimination half life (T(½) of 6.1 to 7.5 h. In summary, there were no serious adverse events up to 22.5 mg dose of crocetin while crocetin was found to be absorbed more quickly than the other carotenoids such as β-carotene, lutein and lycopene. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/21112749/The_pharmacokinetic_profile_of_crocetin_in_healthy_adult_human_volunteers_after_a_single_oral_administration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(10)00342-9 DB - PRIME DP - Unbound Medicine ER -