[Serum anti-endomysium antibodies (AEA) in the diagnostic algorithm of coeliac disease].Epidemiol Mikrobiol Imunol. 2009 Nov; 58(4):163-6.EM
The diagnostic relevance of serum anti-endomysium antibodies (AEA) in patients with celiac disease is discussed. A group of 23 newly diagnosed patients, i.e., seven patients with mild AEA positivity (+), nine patients with intermediate AEA positivity (++) and seven patients with strong AEA positivity (+++), was selected. The AEA reactivity was evaluated semiquantitatively. Celiac disease and AEA are less than 100% correlated. The final diagnosis has to be confirmed by histopathology of small intestine biopsy specimens. The available targeted screening is an alternative with a potential for the detection of atypical forms of celiac disease. Another alternative for early diagnosis is the detection of intraepithelial lymphocyte activity or of lymphocyte mediators.