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Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes.
Int J Sport Nutr Exerc Metab 2010; 20(6):496-506IJ

Abstract

The aim of this investigation was to assess the effects of 6 wk of eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) supplementation on resting and exercise-induced lipid peroxidation and antioxidant status in judoists. Subjects were randomly assigned to receive a placebo or a capsule of polyunsaturated fatty acids (PUFAs; 600 mg EPA and 400 mg DHA). Blood samples were collected in preexercise and postexercise conditions (judo-training session), both before and after the supplementation period. The following parameters were analyzed: α-tocopherol, retinol, lag phase , maximum rate of oxidation (Rmax) during the propagating chain reaction, maximum amount of conjugated dienes (CDmax) accumulated after the propagation phase, nitric oxide (NO) and malondyaldehide (MDA) concentrations, salivary glutathione peroxidase activity, and the lipid profile. Dietary data were collected using a 7-day dietary record. A significant interaction effect between supplementation and time (p < .01) on triglycerides was noted, with values significantly lower in the n-3 long-chain-PUFA (LCPUFA) group after supplementation than in the placebo group. Significant interaction effects between supplementation and time on resting MDA concentrations and Rmax were found (p = .03 and p = .04, respectively), with elevated values in the n-3 LCPUFA group after supplementation and no change in the placebo group's levels. The authors observed a significantly greater NO and oxidative-stress increase with exercise (MDA, Rmax, CDmax, and NO) in the n-3 LCPUFA group than with placebo. No main or interaction effects were found for retinol and α-tocopherol. These results indicate that supplementation with n-3 LCPUFAs significantly increased oxidative stress at rest and after a judo-training session.

Authors+Show Affiliations

Unité de Formation en Sciences et Techniques des Activités Physiques et Sportives, Orleans, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21116022

Citation

Filaire, Edith, et al. "Effect of 6 Weeks of N-3 Fatty-acid Supplementation On Oxidative Stress in Judo Athletes." International Journal of Sport Nutrition and Exercise Metabolism, vol. 20, no. 6, 2010, pp. 496-506.
Filaire E, Massart A, Portier H, et al. Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes. Int J Sport Nutr Exerc Metab. 2010;20(6):496-506.
Filaire, E., Massart, A., Portier, H., Rouveix, M., Rosado, F., Bage, A. S., ... Durand, D. (2010). Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes. International Journal of Sport Nutrition and Exercise Metabolism, 20(6), pp. 496-506.
Filaire E, et al. Effect of 6 Weeks of N-3 Fatty-acid Supplementation On Oxidative Stress in Judo Athletes. Int J Sport Nutr Exerc Metab. 2010;20(6):496-506. PubMed PMID: 21116022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes. AU - Filaire,Edith, AU - Massart,Alain, AU - Portier,Hugues, AU - Rouveix,Matthieu, AU - Rosado,Fatima, AU - Bage,Anne S, AU - Gobert,Mylene, AU - Durand,Denys, PY - 2010/12/1/entrez PY - 2010/12/1/pubmed PY - 2011/2/16/medline SP - 496 EP - 506 JF - International journal of sport nutrition and exercise metabolism JO - Int J Sport Nutr Exerc Metab VL - 20 IS - 6 N2 - The aim of this investigation was to assess the effects of 6 wk of eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) supplementation on resting and exercise-induced lipid peroxidation and antioxidant status in judoists. Subjects were randomly assigned to receive a placebo or a capsule of polyunsaturated fatty acids (PUFAs; 600 mg EPA and 400 mg DHA). Blood samples were collected in preexercise and postexercise conditions (judo-training session), both before and after the supplementation period. The following parameters were analyzed: α-tocopherol, retinol, lag phase , maximum rate of oxidation (Rmax) during the propagating chain reaction, maximum amount of conjugated dienes (CDmax) accumulated after the propagation phase, nitric oxide (NO) and malondyaldehide (MDA) concentrations, salivary glutathione peroxidase activity, and the lipid profile. Dietary data were collected using a 7-day dietary record. A significant interaction effect between supplementation and time (p < .01) on triglycerides was noted, with values significantly lower in the n-3 long-chain-PUFA (LCPUFA) group after supplementation than in the placebo group. Significant interaction effects between supplementation and time on resting MDA concentrations and Rmax were found (p = .03 and p = .04, respectively), with elevated values in the n-3 LCPUFA group after supplementation and no change in the placebo group's levels. The authors observed a significantly greater NO and oxidative-stress increase with exercise (MDA, Rmax, CDmax, and NO) in the n-3 LCPUFA group than with placebo. No main or interaction effects were found for retinol and α-tocopherol. These results indicate that supplementation with n-3 LCPUFAs significantly increased oxidative stress at rest and after a judo-training session. SN - 1526-484X UR - https://www.unboundmedicine.com/medline/citation/21116022/Effect_of_6_Weeks_of_n_3_fatty_acid_supplementation_on_oxidative_stress_in_Judo_athletes_ L2 - https://journals.humankinetics.com/doi/10.1123/ijsnem.20.6.496 DB - PRIME DP - Unbound Medicine ER -