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[Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases].
Postepy Biochem. 2010; 56(3):317-27.PB

Abstract

Living organisms have developed refined and geneticaly controlled mechanisms of the copper metabolism and transport. ATP7A and ATP7B proteins play the key role in copper homeostasis in the organism. Both proteins are P-type Cu-transporting ATPases and use the energy of ATP hydrolysis to transfer the copper ions across the cellular membranes. Both proteins are localised in Golgi aparatus and involved in regulation of overall copper status in the body and their function is the export of excess copper from the cells and delivery of copper ions to Cu-dependent enzymes. Moreover in organism Cu-transporting ATPases are involved in absorption of dietary copper, Cu removal with the bile, placental copper transport and its secretion to the milk during lactation. Moreover it is known that Cu-transporting ATPases play a role in generation of anti-cancer drug resistance. Disturbances of ATP7A and ATP7B function caused by mutations lead to severe metabolic diseases Menkes and Wilson diseases, respectively.

Authors+Show Affiliations

Department of Genetics and Evolution, Institute of Zoology, Jagiellonian University, 6 R. Ingardena St., 30-060 Cracow, Poland. malgorzata.lenartowicz@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

pol

PubMed ID

21117320

Citation

Lenartowicz, Małgorzata, and Wojciech Krzeptowski. "[Structure and Function of ATP7A and ATP7B proteins--Cu-transporting ATPases]." Postepy Biochemii, vol. 56, no. 3, 2010, pp. 317-27.
Lenartowicz M, Krzeptowski W. [Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases]. Postepy Biochem. 2010;56(3):317-27.
Lenartowicz, M., & Krzeptowski, W. (2010). [Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases]. Postepy Biochemii, 56(3), 317-27.
Lenartowicz M, Krzeptowski W. [Structure and Function of ATP7A and ATP7B proteins--Cu-transporting ATPases]. Postepy Biochem. 2010;56(3):317-27. PubMed PMID: 21117320.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Structure and function of ATP7A and ATP7B proteins--Cu-transporting ATPases]. AU - Lenartowicz,Małgorzata, AU - Krzeptowski,Wojciech, PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2010/12/14/medline SP - 317 EP - 27 JF - Postepy biochemii JO - Postepy Biochem VL - 56 IS - 3 N2 - Living organisms have developed refined and geneticaly controlled mechanisms of the copper metabolism and transport. ATP7A and ATP7B proteins play the key role in copper homeostasis in the organism. Both proteins are P-type Cu-transporting ATPases and use the energy of ATP hydrolysis to transfer the copper ions across the cellular membranes. Both proteins are localised in Golgi aparatus and involved in regulation of overall copper status in the body and their function is the export of excess copper from the cells and delivery of copper ions to Cu-dependent enzymes. Moreover in organism Cu-transporting ATPases are involved in absorption of dietary copper, Cu removal with the bile, placental copper transport and its secretion to the milk during lactation. Moreover it is known that Cu-transporting ATPases play a role in generation of anti-cancer drug resistance. Disturbances of ATP7A and ATP7B function caused by mutations lead to severe metabolic diseases Menkes and Wilson diseases, respectively. SN - 0032-5422 UR - https://www.unboundmedicine.com/medline/citation/21117320/[Structure_and_function_of_ATP7A_and_ATP7B_proteins__Cu_transporting_ATPases]_ DB - PRIME DP - Unbound Medicine ER -