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Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet.
Br J Nutr. 2011 Apr; 105(8):1188-98.BJ

Abstract

The present study investigates whether the replacement of dietary casein by soya protein isolate could be able to improve and/or even revert the morphological and metabolic abnormalities underlying the adipose tissue dysfunction of dyslipidaemic rats chronically fed (8 months) a sucrose-rich (62·5 %) diet (SRD). For this purpose, Wistar rats were fed a SRD for 4 months. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein, casein, was substituted by soya. The control group received a diet in which the source of carbohydrate was maize starch. Compared with the SRD-fed group, the results showed that: (1) soya protein decreased body-weight gain, limited the accretion of visceral adiposity and decreased adipose tissue cell volume without changes in total cell number; (2) soya protein increased the protein mass expression of PPARγ, which was significantly reduced in the fat pad of the SRD-fed rats; (3) the activity of the enzymes involved in the de novo lipogenesis of adipose tissue was significantly decreased/normalised; (4) soya protein corrected the inhibitory effect of SRD upon the anti-lipolytic action of insulin, reduced basal lipolysis and normalised the protein mass expression of GLUT-4. Dyslipidaemia, glucose homeostasis and plasma leptin levels returned to control values. The present study provides data showing the beneficial effects of soya protein to improve and/or revert the adipose tissue dysfunction of a dyslipidaemic insulin-resistant rat model and suggests that soya could maintain the functionality of the adipose tissue-liver axis improving/reverting lipotoxicity.

Authors+Show Affiliations

Department of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, Paraje El Pozo, CC 242 (3000), Santa Fe, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21118606

Citation

Oliva, María E., et al. "Soya Protein Ameliorates the Metabolic Abnormalities of Dysfunctional Adipose Tissue of Dyslipidaemic Rats Fed a Sucrose-rich Diet." The British Journal of Nutrition, vol. 105, no. 8, 2011, pp. 1188-98.
Oliva ME, Selenscig D, D'Alessandro ME, et al. Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet. Br J Nutr. 2011;105(8):1188-98.
Oliva, M. E., Selenscig, D., D'Alessandro, M. E., Chicco, A., & Lombardo, Y. B. (2011). Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet. The British Journal of Nutrition, 105(8), 1188-98. https://doi.org/10.1017/S0007114510004915
Oliva ME, et al. Soya Protein Ameliorates the Metabolic Abnormalities of Dysfunctional Adipose Tissue of Dyslipidaemic Rats Fed a Sucrose-rich Diet. Br J Nutr. 2011;105(8):1188-98. PubMed PMID: 21118606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soya protein ameliorates the metabolic abnormalities of dysfunctional adipose tissue of dyslipidaemic rats fed a sucrose-rich diet. AU - Oliva,María E, AU - Selenscig,Dante, AU - D'Alessandro,María E, AU - Chicco,Adriana, AU - Lombardo,Yolanda B, Y1 - 2010/12/01/ PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/5/20/medline SP - 1188 EP - 98 JF - The British journal of nutrition JO - Br J Nutr VL - 105 IS - 8 N2 - The present study investigates whether the replacement of dietary casein by soya protein isolate could be able to improve and/or even revert the morphological and metabolic abnormalities underlying the adipose tissue dysfunction of dyslipidaemic rats chronically fed (8 months) a sucrose-rich (62·5 %) diet (SRD). For this purpose, Wistar rats were fed a SRD for 4 months. From months 4 to 8, half the animals continued with the SRD and the other half were fed a SRD in which the source of protein, casein, was substituted by soya. The control group received a diet in which the source of carbohydrate was maize starch. Compared with the SRD-fed group, the results showed that: (1) soya protein decreased body-weight gain, limited the accretion of visceral adiposity and decreased adipose tissue cell volume without changes in total cell number; (2) soya protein increased the protein mass expression of PPARγ, which was significantly reduced in the fat pad of the SRD-fed rats; (3) the activity of the enzymes involved in the de novo lipogenesis of adipose tissue was significantly decreased/normalised; (4) soya protein corrected the inhibitory effect of SRD upon the anti-lipolytic action of insulin, reduced basal lipolysis and normalised the protein mass expression of GLUT-4. Dyslipidaemia, glucose homeostasis and plasma leptin levels returned to control values. The present study provides data showing the beneficial effects of soya protein to improve and/or revert the adipose tissue dysfunction of a dyslipidaemic insulin-resistant rat model and suggests that soya could maintain the functionality of the adipose tissue-liver axis improving/reverting lipotoxicity. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21118606/Soya_protein_ameliorates_the_metabolic_abnormalities_of_dysfunctional_adipose_tissue_of_dyslipidaemic_rats_fed_a_sucrose_rich_diet_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510004915/type/journal_article DB - PRIME DP - Unbound Medicine ER -