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Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy.
Neuroscience. 2011 Feb 03; 174:190-9.N

Abstract

Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and l-serine concentration were examined. Effects of l-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the l-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of l-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of l-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived l-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy.

Authors+Show Affiliations

Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21118710

Citation

Kiya, T, et al. "Role of Satellite Cell-derived L-serine in the Dorsal Root Ganglion in Paclitaxel-induced Painful Peripheral Neuropathy." Neuroscience, vol. 174, 2011, pp. 190-9.
Kiya T, Kawamata T, Namiki A, et al. Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. Neuroscience. 2011;174:190-9.
Kiya, T., Kawamata, T., Namiki, A., & Yamakage, M. (2011). Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. Neuroscience, 174, 190-9. https://doi.org/10.1016/j.neuroscience.2010.11.046
Kiya T, et al. Role of Satellite Cell-derived L-serine in the Dorsal Root Ganglion in Paclitaxel-induced Painful Peripheral Neuropathy. Neuroscience. 2011 Feb 3;174:190-9. PubMed PMID: 21118710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy. AU - Kiya,T, AU - Kawamata,T, AU - Namiki,A, AU - Yamakage,M, Y1 - 2010/11/29/ PY - 2010/08/31/received PY - 2010/11/22/revised PY - 2010/11/22/accepted PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/6/22/medline SP - 190 EP - 9 JF - Neuroscience JO - Neuroscience VL - 174 N2 - Paclitaxel is one of the most commonly used anti-neoplastic drugs for the treatment of solid tumors. Unfortunately, its use is often associated with dose-limiting painful peripheral neuropathy and subsequent neuropathic pain that is resistant to standard analgesics. However, there are few clinically available drugs or drug classes for the treatment of paclitaxel-induced neuropathy due to a lack of information regarding the mechanisms responsible for it. In this study, we examined the involvement of l-serine in paclitaxel-induced hyperalgesia/allodynia and decrease in sensory nerve conduction velocity (SNCV). We used a preclinical rat model of paclitaxel-induced painful peripheral neuropathy. Response to von Frey filaments, SNCV, 3-phosphoglycerate dehydrogenase (3PGDH) expression, and l-serine concentration were examined. Effects of l-serine administration were also investigated. Paclitaxel treatment induced mechanical allodynia/hyperalgesia and reduction of SNCV. Paclitaxel also decreased the l-serine concentration in the dorsal root ganglion (DRG) but not in the sciatic nerve or spinal cord. In addition, paclitaxel decreased expression of 3PGDH, a biosynthetic enzyme of l-serine, in the DRG. Immunohistochemistry showed that 3PGDH was localized in satellite cells but not in neurons in the DRG. Intraperitoneal administration of l-serine improved both paclitaxel-induced mechanical allodynia/hyperalgesia and the reduction of SNCV. These results suggest that satellite cell-derived l-serine in the DRG plays an important role in paclitaxel-induced painful peripheral neuropathy. These findings may lead to novel strategies for the treatment of paclitaxel-induced painful peripheral neuropathy. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/21118710/Role_of_satellite_cell_derived_L_serine_in_the_dorsal_root_ganglion_in_paclitaxel_induced_painful_peripheral_neuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(10)01537-X DB - PRIME DP - Unbound Medicine ER -