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Analytic review: glucose controversies in the ICU.
J Intensive Care Med. 2011 May-Jun; 26(3):135-50.JI

Abstract

Hyperglycemia is common in critical illness and has been associated with increased morbidity and mortality. An era of tight glucose control began when intensive insulin therapy was shown to improve outcomes in a single-center randomized trial. More recently, with the publication of additional studies, questions have been raised regarding the efficacy and safety of intensive glycemic management. This article will review the biologic mechanisms that may help us understand why and how hyperglycemia and insulin are relevant in critical illness. We will then explore insights gleaned from available clinical trials. Finally, we will discuss specific areas of controversy that relate to the implementation of glycemic control in the intensive care unit, such as the ideal glucose target and the importance of hypoglycemia.

Authors+Show Affiliations

Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT, USA. shyoko.honiden@yale.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21118863

Citation

Honiden, Shyoko, and Silvio E. Inzucchi. "Analytic Review: Glucose Controversies in the ICU." Journal of Intensive Care Medicine, vol. 26, no. 3, 2011, pp. 135-50.
Honiden S, Inzucchi SE. Analytic review: glucose controversies in the ICU. J Intensive Care Med. 2011;26(3):135-50.
Honiden, S., & Inzucchi, S. E. (2011). Analytic review: glucose controversies in the ICU. Journal of Intensive Care Medicine, 26(3), 135-50. https://doi.org/10.1177/0885066610387892
Honiden S, Inzucchi SE. Analytic Review: Glucose Controversies in the ICU. J Intensive Care Med. 2011 May-Jun;26(3):135-50. PubMed PMID: 21118863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytic review: glucose controversies in the ICU. AU - Honiden,Shyoko, AU - Inzucchi,Silvio E, Y1 - 2010/11/30/ PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/10/8/medline SP - 135 EP - 50 JF - Journal of intensive care medicine JO - J Intensive Care Med VL - 26 IS - 3 N2 - Hyperglycemia is common in critical illness and has been associated with increased morbidity and mortality. An era of tight glucose control began when intensive insulin therapy was shown to improve outcomes in a single-center randomized trial. More recently, with the publication of additional studies, questions have been raised regarding the efficacy and safety of intensive glycemic management. This article will review the biologic mechanisms that may help us understand why and how hyperglycemia and insulin are relevant in critical illness. We will then explore insights gleaned from available clinical trials. Finally, we will discuss specific areas of controversy that relate to the implementation of glycemic control in the intensive care unit, such as the ideal glucose target and the importance of hypoglycemia. SN - 1525-1489 UR - https://www.unboundmedicine.com/medline/citation/21118863/Analytic_review:_glucose_controversies_in_the_ICU_ L2 - https://journals.sagepub.com/doi/10.1177/0885066610387892?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -