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Retrieval induces reconsolidation of fear extinction memory.
Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21801-5.PN

Abstract

The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus.

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Authors+Show Affiliations

Rossato JI
Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul and Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, RS90610-000 Porto Alegre, Brazil.
Bevilaqua LR
No affiliation info available
Izquierdo I
No affiliation info available
Medina JH
No affiliation info available
Cammarota M
No affiliation info available

MeSH

AnimalsAvoidance LearningExtinction, PsychologicalFearHippocampusMaleMemoryNeuropsychological TestsRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21118982

Citation

Rossato, Janine I., et al. "Retrieval Induces Reconsolidation of Fear Extinction Memory." Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 50, 2010, pp. 21801-5.
Rossato JI, Bevilaqua LR, Izquierdo I, et al. Retrieval induces reconsolidation of fear extinction memory. Proc Natl Acad Sci U S A. 2010;107(50):21801-5.
Rossato, J. I., Bevilaqua, L. R., Izquierdo, I., Medina, J. H., & Cammarota, M. (2010). Retrieval induces reconsolidation of fear extinction memory. Proceedings of the National Academy of Sciences of the United States of America, 107(50), 21801-5. https://doi.org/10.1073/pnas.1016254107
Rossato JI, et al. Retrieval Induces Reconsolidation of Fear Extinction Memory. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21801-5. PubMed PMID: 21118982.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrieval induces reconsolidation of fear extinction memory. AU - Rossato,Janine I, AU - Bevilaqua,Lia R, AU - Izquierdo,Iván, AU - Medina,Jorge H, AU - Cammarota,Martín, Y1 - 2010/11/30/ PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/5/13/medline SP - 21801 EP - 5 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 107 IS - 50 N2 - The nonreinforced expression of long-tem memory may lead to two opposite protein synthesis-dependent processes: extinction and reconsolidation. Extinction weakens consolidated memories, whereas reconsolidation allows incorporation of additional information into them. Knowledge about these two processes has accumulated in recent years, but their possible interaction has not been evaluated yet. Here, we report that inhibition of protein synthesis in the CA1 region of the dorsal hippocampus after retrieval of fear extinction impedes subsequent reactivation of the extinction memory trace without affecting its storage or that of the initial fear memory. Our results suggest that extinction memory is susceptible to a retrieval-induced process similar to reconsolidation in the hippocampus. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/21118982/Retrieval_induces_reconsolidation_of_fear_extinction_memory_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=21118982 DB - PRIME DP - Unbound Medicine ER -