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Pure seminoma in the setting of androgen insensitivity syndrome treated with surgical resection and para-aortic radiation: a case report and review of literature.
J Cancer Res Ther. 2010 Jul-Sep; 6(3):318-20.JC

Abstract

Complete androgen insensitivity is a rare X-linked disorder characterized by a female phenotype in a chromosomally male individual. Malignant transformation of the un-descended testis is a rare phenomena compared to other inter-sex syndromes. This is a case of a 32-year-old female who was diagnosed with androgen insensitivity and presented to the emergency room with pelvic pain. Later the pelvic pain was found to be due to testicular masses, one of which was pure seminoma. We reviewed the literature emphasizing the biochemical and endocrinologic abnormalities leading to the syndrome, as well as the potential for malignant changes of the un-descended testes, diagnosis, and therapeutic management. We discuss the importance of early diagnosis and the consequence associated with misdiagnosis.

Authors+Show Affiliations

Stich Radiation Center, Weill Cornell Medical Center, 525E 68th street, New York, NY 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21119263

Citation

Herman, Michael, et al. "Pure Seminoma in the Setting of Androgen Insensitivity Syndrome Treated With Surgical Resection and Para-aortic Radiation: a Case Report and Review of Literature." Journal of Cancer Research and Therapeutics, vol. 6, no. 3, 2010, pp. 318-20.
Herman M, Wernicke GA, Yan W, et al. Pure seminoma in the setting of androgen insensitivity syndrome treated with surgical resection and para-aortic radiation: a case report and review of literature. J Cancer Res Ther. 2010;6(3):318-20.
Herman, M., Wernicke, G. A., Yan, W., Nori, D., & Parashar, B. (2010). Pure seminoma in the setting of androgen insensitivity syndrome treated with surgical resection and para-aortic radiation: a case report and review of literature. Journal of Cancer Research and Therapeutics, 6(3), 318-20. https://doi.org/10.4103/0973-1482.73337
Herman M, et al. Pure Seminoma in the Setting of Androgen Insensitivity Syndrome Treated With Surgical Resection and Para-aortic Radiation: a Case Report and Review of Literature. J Cancer Res Ther. 2010 Jul-Sep;6(3):318-20. PubMed PMID: 21119263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pure seminoma in the setting of androgen insensitivity syndrome treated with surgical resection and para-aortic radiation: a case report and review of literature. AU - Herman,Michael, AU - Wernicke,Gabriella A, AU - Yan,Weisi, AU - Nori,Dattatreyudu, AU - Parashar,Bhupesh, PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/3/24/medline SP - 318 EP - 20 JF - Journal of cancer research and therapeutics JO - J Cancer Res Ther VL - 6 IS - 3 N2 - Complete androgen insensitivity is a rare X-linked disorder characterized by a female phenotype in a chromosomally male individual. Malignant transformation of the un-descended testis is a rare phenomena compared to other inter-sex syndromes. This is a case of a 32-year-old female who was diagnosed with androgen insensitivity and presented to the emergency room with pelvic pain. Later the pelvic pain was found to be due to testicular masses, one of which was pure seminoma. We reviewed the literature emphasizing the biochemical and endocrinologic abnormalities leading to the syndrome, as well as the potential for malignant changes of the un-descended testes, diagnosis, and therapeutic management. We discuss the importance of early diagnosis and the consequence associated with misdiagnosis. SN - 1998-4138 UR - https://www.unboundmedicine.com/medline/citation/21119263/Pure_seminoma_in_the_setting_of_androgen_insensitivity_syndrome_treated_with_surgical_resection_and_para_aortic_radiation:_a_case_report_and_review_of_literature_ L2 - http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2010;volume=6;issue=3;spage=318;epage=320;aulast=Herman DB - PRIME DP - Unbound Medicine ER -
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