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Candidate gene studies of fibromyalgia: a systematic review and meta-analysis.
Rheumatol Int 2012; 32(2):417-26RI

Abstract

The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. lyhcgh@korea.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

21120487

Citation

Lee, Young Ho, et al. "Candidate Gene Studies of Fibromyalgia: a Systematic Review and Meta-analysis." Rheumatology International, vol. 32, no. 2, 2012, pp. 417-26.
Lee YH, Choi SJ, Ji JD, et al. Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatol Int. 2012;32(2):417-26.
Lee, Y. H., Choi, S. J., Ji, J. D., & Song, G. G. (2012). Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. Rheumatology International, 32(2), pp. 417-26. doi:10.1007/s00296-010-1678-9.
Lee YH, et al. Candidate Gene Studies of Fibromyalgia: a Systematic Review and Meta-analysis. Rheumatol Int. 2012;32(2):417-26. PubMed PMID: 21120487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Candidate gene studies of fibromyalgia: a systematic review and meta-analysis. AU - Lee,Young Ho, AU - Choi,Sung Jae, AU - Ji,Jong Dae, AU - Song,Gwan Gyu, Y1 - 2010/12/01/ PY - 2010/06/24/received PY - 2010/11/14/accepted PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2012/10/16/medline SP - 417 EP - 26 JF - Rheumatology international JO - Rheumatol. Int. VL - 32 IS - 2 N2 - The aim of this study was to explore whether the candidate gene polymorphisms contribute to fibromyalgia susceptibility. The authors conducted a meta-analysis on associations between serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) S/L allele, catechol-O-methltransferase (COMT) val158Met, and serotonin 2A (5-HT2A) receptor 102T/C polymorphisms and fibromyalgia susceptibility as determined using the following: (1) allele contrast, (2) recessive, (3) dominant models, and (4) contrast of homozygotes. We also performed a systematic review with available data of the candidate genes. A total of 21 separate comparisons were considered in this systematic review and meta-analysis. Seventeen candidate genes and over 35 different polymorphisms were identified in studies on fibromyalgia susceptibility. Meta-analysis of the 5-HTTLPR S/L allele and COMT val158Met failed to reveal any association with fibromyalgia. However, meta-analysis of the C allele, CC + CT genotype, and CC versus TT genotype of the 5-HT2A receptor 102T/C polymorphism showed significant association with fibromyalgia. The overall OR of the association between the C allele and fibromyalgia was 1.333 (95% CI = 1.053-1.688, P = 0.017). The ORs for the CC + CT genotype, and CC versus TT genotype showed the same pattern as that observed for the C allele (OR = 1.541, 95% CI = 1.032-2.303, P = 0.035; OR = 1.838, 95% CI = 1.151-2.936, P = 0.011). This meta-analysis demonstrates that the 5-HT2A receptor 102T/C polymorphism confers susceptibility to fibromyalgia. In contrast, no association was found between the 5-HTTLPR S/L allele, COMT val158Met, and susceptibility to fibromyalgia. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/21120487/Candidate_gene_studies_of_fibromyalgia:_a_systematic_review_and_meta_analysis_ L2 - https://dx.doi.org/10.1007/s00296-010-1678-9 DB - PRIME DP - Unbound Medicine ER -