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Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances.
Arch Gynecol Obstet 2011; 284(4):913-21AG

Abstract

PURPOSE

To assess the effects of Kampo, a traditional Japanese adaptation of Chinese herbal medicine, on peri- and postmenopausal women with sleep disturbances.

METHODS

Among the records of 1,523 peri- and postmenopausal women who are enrolled in the Health and Nutrition Education Program at the Tokyo Medical and Dental University, Menopause Clinic, during 1995-2009, about 151 women suffering from moderate to severe sleep disturbances were retrospectively analyzed. These women had received only health/nutrition education (control; n = 77) or received treatment with one of the three major Kampo formulae: Tokishakuyakusan (TJ-23; n = 42), Kamishoyosan (TJ-24; n = 16), or Keishibukuryogan (TJ-25; n = 16) according to their "Sho" or symptom patterns. Subjective sleep parameters, menopausal symptoms, health-related quality of life, body composition, blood pressure, and pulse rate were compared before and after the intervention.

RESULTS

The TJ-25 group had significantly higher body weight, body mass index, body fat, lean body mass, resting energy expenditure, and relatively high blood pressure and heart rate at baseline than the other groups. After ~5-month follow up, TJ-23 reduced the sleep disruption frequency, increased lean body mass, and decreased diastolic pressure. TJ-24 alleviated subjective sleep disturbances; improved difficulties in initiating sleep, disrupted sleep, and non-restorative sleep; and relieved headache/dizziness. TJ-25 improved subjective sleep disturbances, alleviated perspiration, and reduced systolic/diastolic pressure and heart rate.

CONCLUSIONS

Each of the Kampo formulae effectively alleviated sleep disturbances in Japanese peri- and postmenopausal women. Middle-aged female patients having sleeping disorder could successfully be treated using Kampo medicines.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo, Tokyo 113-8510, Japan. teragyne@tmd.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21120510

Citation

Terauchi, Masakazu, et al. "Effects of Three Kampo Formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) On Japanese Peri- and Postmenopausal Women With Sleep Disturbances." Archives of Gynecology and Obstetrics, vol. 284, no. 4, 2011, pp. 913-21.
Terauchi M, Hiramitsu S, Akiyoshi M, et al. Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. Arch Gynecol Obstet. 2011;284(4):913-21.
Terauchi, M., Hiramitsu, S., Akiyoshi, M., Owa, Y., Kato, K., Obayashi, S., ... Kubota, T. (2011). Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. Archives of Gynecology and Obstetrics, 284(4), pp. 913-21. doi:10.1007/s00404-010-1779-4.
Terauchi M, et al. Effects of Three Kampo Formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) On Japanese Peri- and Postmenopausal Women With Sleep Disturbances. Arch Gynecol Obstet. 2011;284(4):913-21. PubMed PMID: 21120510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. AU - Terauchi,Masakazu, AU - Hiramitsu,Shiro, AU - Akiyoshi,Mihoko, AU - Owa,Yoko, AU - Kato,Kiyoko, AU - Obayashi,Satoshi, AU - Matsushima,Eisuke, AU - Kubota,Toshiro, Y1 - 2010/12/01/ PY - 2010/09/30/received PY - 2010/11/11/accepted PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2012/1/13/medline SP - 913 EP - 21 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 284 IS - 4 N2 - PURPOSE: To assess the effects of Kampo, a traditional Japanese adaptation of Chinese herbal medicine, on peri- and postmenopausal women with sleep disturbances. METHODS: Among the records of 1,523 peri- and postmenopausal women who are enrolled in the Health and Nutrition Education Program at the Tokyo Medical and Dental University, Menopause Clinic, during 1995-2009, about 151 women suffering from moderate to severe sleep disturbances were retrospectively analyzed. These women had received only health/nutrition education (control; n = 77) or received treatment with one of the three major Kampo formulae: Tokishakuyakusan (TJ-23; n = 42), Kamishoyosan (TJ-24; n = 16), or Keishibukuryogan (TJ-25; n = 16) according to their "Sho" or symptom patterns. Subjective sleep parameters, menopausal symptoms, health-related quality of life, body composition, blood pressure, and pulse rate were compared before and after the intervention. RESULTS: The TJ-25 group had significantly higher body weight, body mass index, body fat, lean body mass, resting energy expenditure, and relatively high blood pressure and heart rate at baseline than the other groups. After ~5-month follow up, TJ-23 reduced the sleep disruption frequency, increased lean body mass, and decreased diastolic pressure. TJ-24 alleviated subjective sleep disturbances; improved difficulties in initiating sleep, disrupted sleep, and non-restorative sleep; and relieved headache/dizziness. TJ-25 improved subjective sleep disturbances, alleviated perspiration, and reduced systolic/diastolic pressure and heart rate. CONCLUSIONS: Each of the Kampo formulae effectively alleviated sleep disturbances in Japanese peri- and postmenopausal women. Middle-aged female patients having sleeping disorder could successfully be treated using Kampo medicines. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/21120510/Effects_of_three_Kampo_formulae:_Tokishakuyakusan__TJ_23__Kamishoyosan__TJ_24__and_Keishibukuryogan__TJ_25__on_Japanese_peri__and_postmenopausal_women_with_sleep_disturbances_ L2 - https://dx.doi.org/10.1007/s00404-010-1779-4 DB - PRIME DP - Unbound Medicine ER -