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Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study.
Int J Cancer 2011; 129(7):1718-29IJ

Abstract

To date, epidemiologic studies investigating intake of n-3 and n-6 polyunsaturated fatty acids and risk of colorectal cancer are limited, and results remain inconsistent. This is the first prospective study to show the association by subsite (proximal colon, distal colon, rectum). To clarify the role of n-3 and n-6 polyunsaturated fatty acids intake in colon carcinogenesis, we conducted a large, population-based prospective study, characterized by high fish consumption and a wide range of n-3 polyunsaturated fatty acids intakes. Subjects were followed from response to a lifestyle questionnaire in 1995-1999 through 2006. During 827,833 person-years of follow-up (average 9.3 years), we identified 1,268 new colorectal cancer cases (521 colon and 253 rectal for men; 350 colon and 144 rectal for women). Compared to the lowest quintile, the relative risk and 95% confidence interval of developing cancer among the fifth quintile of marine n-3 polyunsaturated fatty acids intake were 0.60 and 0.31-1.14, respectively (p for trend = 0.04) in the colon in women and 0.35 and 0.14-0.88 (p for trend = 0.05) and 1.82 and 0.79-4.20 (p for trend = 0.16) in the proximal and distal colon, respectively, in men. For rectal cancer, the dose response for marine n-3 polyunsaturated fatty acids s was unclear; rather, we observed U-shaped associations in men and women. We found no evidence that n-6 polyunsaturated fatty acids increases or the n-3/n-6 ratio decreases the risk of colorectal cancer. Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel.

Authors+Show Affiliations

Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan. ssasazuk@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21120874

Citation

Sasazuki, Shizuka, et al. "Intake of N-3 and N-6 Polyunsaturated Fatty Acids and Development of Colorectal Cancer By Subsite: Japan Public Health Center-based Prospective Study." International Journal of Cancer, vol. 129, no. 7, 2011, pp. 1718-29.
Sasazuki S, Inoue M, Iwasaki M, et al. Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study. Int J Cancer. 2011;129(7):1718-29.
Sasazuki, S., Inoue, M., Iwasaki, M., Sawada, N., Shimazu, T., Yamaji, T., ... Tsugane, S. (2011). Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study. International Journal of Cancer, 129(7), pp. 1718-29. doi:10.1002/ijc.25802.
Sasazuki S, et al. Intake of N-3 and N-6 Polyunsaturated Fatty Acids and Development of Colorectal Cancer By Subsite: Japan Public Health Center-based Prospective Study. Int J Cancer. 2011 Oct 1;129(7):1718-29. PubMed PMID: 21120874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study. AU - Sasazuki,Shizuka, AU - Inoue,Manami, AU - Iwasaki,Motoki, AU - Sawada,Norie, AU - Shimazu,Taichi, AU - Yamaji,Taiki, AU - Takachi,Ribeka, AU - Tsugane,Shoichiro, AU - ,, Y1 - 2011/04/01/ PY - 2010/07/23/received PY - 2010/11/03/accepted PY - 2010/12/2/entrez PY - 2010/12/2/pubmed PY - 2011/9/21/medline SP - 1718 EP - 29 JF - International journal of cancer JO - Int. J. Cancer VL - 129 IS - 7 N2 - To date, epidemiologic studies investigating intake of n-3 and n-6 polyunsaturated fatty acids and risk of colorectal cancer are limited, and results remain inconsistent. This is the first prospective study to show the association by subsite (proximal colon, distal colon, rectum). To clarify the role of n-3 and n-6 polyunsaturated fatty acids intake in colon carcinogenesis, we conducted a large, population-based prospective study, characterized by high fish consumption and a wide range of n-3 polyunsaturated fatty acids intakes. Subjects were followed from response to a lifestyle questionnaire in 1995-1999 through 2006. During 827,833 person-years of follow-up (average 9.3 years), we identified 1,268 new colorectal cancer cases (521 colon and 253 rectal for men; 350 colon and 144 rectal for women). Compared to the lowest quintile, the relative risk and 95% confidence interval of developing cancer among the fifth quintile of marine n-3 polyunsaturated fatty acids intake were 0.60 and 0.31-1.14, respectively (p for trend = 0.04) in the colon in women and 0.35 and 0.14-0.88 (p for trend = 0.05) and 1.82 and 0.79-4.20 (p for trend = 0.16) in the proximal and distal colon, respectively, in men. For rectal cancer, the dose response for marine n-3 polyunsaturated fatty acids s was unclear; rather, we observed U-shaped associations in men and women. We found no evidence that n-6 polyunsaturated fatty acids increases or the n-3/n-6 ratio decreases the risk of colorectal cancer. Our results suggest that intake of marine n-3 polyunsaturated fatty acids may be inversely related to the risk of cancer in the proximal site of the large bowel. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/21120874/Intake_of_n_3_and_n_6_polyunsaturated_fatty_acids_and_development_of_colorectal_cancer_by_subsite:_Japan_Public_Health_Center_based_prospective_study_ L2 - https://doi.org/10.1002/ijc.25802 DB - PRIME DP - Unbound Medicine ER -