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Facial skeletal morphology in growing children with Pierre Robin sequence.
Cleft Palate Craniofac J. 2012 Sep; 49(5):553-60.CP

Abstract

OBJECTIVE

The purpose was to compare the jaw size, jaw relationship, and facial proportions of children with nonsyndromic Pierre Robin sequence with children with nonsyndromic or isolated cleft palate.

DESIGN

This is a retrospective cohort study comparing radiographic findings in children with Pierre Robin sequence or isolated cleft palate at two time intervals: ages 4 to 7 years (T1) and ages 10 to 13 years (T2). Linear and angular measurements were obtained using cephalograms; the cephalometric values were compared with unpaired t tests, assuming unequal variances.

SETTING

The study was conducted at the Center for Craniofacial Anomalies at the University of California, San Francisco.

PATIENTS

The sample included 13 children with Pierre Robin sequence and 14 children with isolated cleft palate who were followed at University of California, San Francisco, craniofacial anomalies clinic during the period from 1971 to 2007 and met the inclusion criteria.

MAIN OUTCOME MEASURES

The outcome measures were mandibular length, maxillary length, and sagittal jaw relationship in Pierre Robin sequence and isolated cleft palate children at T1 and T2.

RESULTS

During early childhood (T1: 4 to 7 years), mandibular length (Co-Gn) was similar in both Pierre Robin sequence and isolated cleft palate groups, as was the maxillary length (Co-A). In older children (T2: 10 to 13 years) mandibular length was significantly shorter in the Pierre Robin sequence group compared with the isolated cleft palate group (difference = 10.9 mm, p = .009). Maxillary length in Pierre Robin sequence and isolated cleft palate groups was similar at T2 but significantly shorter in comparison to age-matched norms with a difference of 14.5 mm (p = .037) for Pierre Robin sequence and 12.4 mm (p = .045) for isolated cleft palate. Children with Pierre Robin sequence did not show a sagittal jaw discrepancy due to a proportionate deficiency in maxillary and mandibular length; whereas, children with isolated cleft palate showed a greater sagittal jaw discrepancy due to normal mandibular length and deficiency in maxillary length.

CONCLUSION

Our study confirms the findings of some previous studies that suggest that children with nonsyndromic Pierre Robin sequence have a proportionate retrusion of the maxilla and mandible, resulting in a convex facial profile by early adolescence.

Authors+Show Affiliations

Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA 94143, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21121765

Citation

Shen, Yoshi F., et al. "Facial Skeletal Morphology in Growing Children With Pierre Robin Sequence." The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, vol. 49, no. 5, 2012, pp. 553-60.
Shen YF, Vargervik K, Oberoi S, et al. Facial skeletal morphology in growing children with Pierre Robin sequence. Cleft Palate Craniofac J. 2012;49(5):553-60.
Shen, Y. F., Vargervik, K., Oberoi, S., & Chigurupati, R. (2012). Facial skeletal morphology in growing children with Pierre Robin sequence. The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, 49(5), 553-60. https://doi.org/10.1597/09-154
Shen YF, et al. Facial Skeletal Morphology in Growing Children With Pierre Robin Sequence. Cleft Palate Craniofac J. 2012;49(5):553-60. PubMed PMID: 21121765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facial skeletal morphology in growing children with Pierre Robin sequence. AU - Shen,Yoshi F, AU - Vargervik,Karin, AU - Oberoi,Snehlata, AU - Chigurupati,Radhika, Y1 - 2010/11/30/ PY - 2010/12/3/entrez PY - 2010/12/3/pubmed PY - 2015/9/29/medline SP - 553 EP - 60 JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JO - Cleft Palate Craniofac J VL - 49 IS - 5 N2 - OBJECTIVE: The purpose was to compare the jaw size, jaw relationship, and facial proportions of children with nonsyndromic Pierre Robin sequence with children with nonsyndromic or isolated cleft palate. DESIGN: This is a retrospective cohort study comparing radiographic findings in children with Pierre Robin sequence or isolated cleft palate at two time intervals: ages 4 to 7 years (T1) and ages 10 to 13 years (T2). Linear and angular measurements were obtained using cephalograms; the cephalometric values were compared with unpaired t tests, assuming unequal variances. SETTING: The study was conducted at the Center for Craniofacial Anomalies at the University of California, San Francisco. PATIENTS: The sample included 13 children with Pierre Robin sequence and 14 children with isolated cleft palate who were followed at University of California, San Francisco, craniofacial anomalies clinic during the period from 1971 to 2007 and met the inclusion criteria. MAIN OUTCOME MEASURES: The outcome measures were mandibular length, maxillary length, and sagittal jaw relationship in Pierre Robin sequence and isolated cleft palate children at T1 and T2. RESULTS: During early childhood (T1: 4 to 7 years), mandibular length (Co-Gn) was similar in both Pierre Robin sequence and isolated cleft palate groups, as was the maxillary length (Co-A). In older children (T2: 10 to 13 years) mandibular length was significantly shorter in the Pierre Robin sequence group compared with the isolated cleft palate group (difference = 10.9 mm, p = .009). Maxillary length in Pierre Robin sequence and isolated cleft palate groups was similar at T2 but significantly shorter in comparison to age-matched norms with a difference of 14.5 mm (p = .037) for Pierre Robin sequence and 12.4 mm (p = .045) for isolated cleft palate. Children with Pierre Robin sequence did not show a sagittal jaw discrepancy due to a proportionate deficiency in maxillary and mandibular length; whereas, children with isolated cleft palate showed a greater sagittal jaw discrepancy due to normal mandibular length and deficiency in maxillary length. CONCLUSION: Our study confirms the findings of some previous studies that suggest that children with nonsyndromic Pierre Robin sequence have a proportionate retrusion of the maxilla and mandible, resulting in a convex facial profile by early adolescence. SN - 1545-1569 UR - https://www.unboundmedicine.com/medline/citation/21121765/Facial_skeletal_morphology_in_growing_children_with_Pierre_Robin_sequence_ L2 - https://journals.sagepub.com/doi/10.1597/09-154?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -