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Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice.
Protein Pept Lett. 2011 Apr; 18(4):403-9.PP

Abstract

Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspinal NPFF system on analgesia induced by opiates administered at the peripheral level. In the present study, intracerebroventricular (i.c.v.) injection of NPFF (1, 3 and 10 nmol) dose-dependently inhibited systemic morphine (0.12 mg, i.p.) analgesia in the mouse tail flick test. Similarly, i.c.v. administration of dNPA and NPVF, two agonists highly selective for NPFF(2) and NPFF(1) receptors, respectively, decreased analgesia induced by i.p. morphine in mice. Furthermore, these anti-opioid activities of NPFF and related peptides were blocked by pretreatment with the NPFF receptors selective antagonist RF9 (10 nmol, i.c.v.). These results demonstrate that activation of central NPFF(1) and NPFF(2) receptors has the similar anti-opioid actions on the antinociceptive effect of systemic morphine.

Authors+Show Affiliations

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Medicine, Lanzhou University, 222 Tian Shui South Road, Lanzhou, 730000, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21121889

Citation

Fang, Quan, et al. "Central Administration of Neuropeptide FF and Related Peptides Attenuate Systemic Morphine Analgesia in Mice." Protein and Peptide Letters, vol. 18, no. 4, 2011, pp. 403-9.
Fang Q, Jiang TN, Li N, et al. Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice. Protein Pept Lett. 2011;18(4):403-9.
Fang, Q., Jiang, T. N., Li, N., Han, Z. L., & Wang, R. (2011). Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice. Protein and Peptide Letters, 18(4), 403-9.
Fang Q, et al. Central Administration of Neuropeptide FF and Related Peptides Attenuate Systemic Morphine Analgesia in Mice. Protein Pept Lett. 2011;18(4):403-9. PubMed PMID: 21121889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central administration of neuropeptide FF and related peptides attenuate systemic morphine analgesia in mice. AU - Fang,Quan, AU - Jiang,Tian-nan, AU - Li,Ning, AU - Han,Zheng-lan, AU - Wang,Rui, PY - 2010/09/08/received PY - 2010/11/25/accepted PY - 2010/12/3/entrez PY - 2010/12/3/pubmed PY - 2011/7/9/medline SP - 403 EP - 9 JF - Protein and peptide letters JO - Protein Pept Lett VL - 18 IS - 4 N2 - Neuropeptide FF (NPFF) belongs to an opioid-modulating peptide family. NPFF has been reported to play important roles in the control of pain and analgesia through interactions with the opioid system. However, very few studies examined the effect of supraspinal NPFF system on analgesia induced by opiates administered at the peripheral level. In the present study, intracerebroventricular (i.c.v.) injection of NPFF (1, 3 and 10 nmol) dose-dependently inhibited systemic morphine (0.12 mg, i.p.) analgesia in the mouse tail flick test. Similarly, i.c.v. administration of dNPA and NPVF, two agonists highly selective for NPFF(2) and NPFF(1) receptors, respectively, decreased analgesia induced by i.p. morphine in mice. Furthermore, these anti-opioid activities of NPFF and related peptides were blocked by pretreatment with the NPFF receptors selective antagonist RF9 (10 nmol, i.c.v.). These results demonstrate that activation of central NPFF(1) and NPFF(2) receptors has the similar anti-opioid actions on the antinociceptive effect of systemic morphine. SN - 1875-5305 UR - https://www.unboundmedicine.com/medline/citation/21121889/Central_administration_of_neuropeptide_FF_and_related_peptides_attenuate_systemic_morphine_analgesia_in_mice_ L2 - https://www.eurekaselect.com/87536/article DB - PRIME DP - Unbound Medicine ER -