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Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987.
JAMA 1990; 263(24):3281-5JAMA

Abstract

Outbreaks of acute hepatitis occurred in Huitzililla and Telixtac, two rural villages 70 miles south of Mexico City, Mexico, in late 1986. The first outbreak began in Huitzililla in June of that year, 1 month after the start of the rainy season. A census revealed 94 icteric case subjects, for an attack rate of 5%; two women died. Attack rates were higher for persons older than 15 years (10%) than for younger persons. A case-control study showed that illness was highly associated with water-related factors. The second outbreak began in August 1986 in Telixtac. There were 129 case subjects, for an attack rate of 6%; one woman died. Epidemiologic findings were similar to those in Huitzililla, except that most disease transmission was not linked to unsafe water sources. None of 62 case subjects in Huitzililla and only 2 of 53 case subjects in Telixtac tested had serological evidence for recent infection with hepatitis A or B. Two of eight stool samples from Huitzililla and one of the eight stool samples from Telixtac were positive by immune electron microscopy for 32- to 34-nm viruslike particles similar to those seen in cases of enterically transmitted non-A, non-B hepatitis from Asia. To our knowledge, these investigations document for the first time the epidemic transmission of enterically transmitted non-A, non-B hepatitis virus in the Americas.

Authors+Show Affiliations

Residency Program in Applied Epidemiology, Secretariat of Health, Mexico City, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2112204

Citation

Velázquez, O, et al. "Epidemic Transmission of Enterically Transmitted non-A, non-B Hepatitis in Mexico, 1986-1987." JAMA, vol. 263, no. 24, 1990, pp. 3281-5.
Velázquez O, Stetler HC, Avila C, et al. Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987. JAMA. 1990;263(24):3281-5.
Velázquez, O., Stetler, H. C., Avila, C., Ornelas, G., Alvarez, C., Hadler, S. C., ... Sepúlveda, J. (1990). Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987. JAMA, 263(24), pp. 3281-5.
Velázquez O, et al. Epidemic Transmission of Enterically Transmitted non-A, non-B Hepatitis in Mexico, 1986-1987. JAMA. 1990 Jun 27;263(24):3281-5. PubMed PMID: 2112204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987. AU - Velázquez,O, AU - Stetler,H C, AU - Avila,C, AU - Ornelas,G, AU - Alvarez,C, AU - Hadler,S C, AU - Bradley,D W, AU - Sepúlveda,J, PY - 1990/6/27/pubmed PY - 1990/6/27/medline PY - 1990/6/27/entrez SP - 3281 EP - 5 JF - JAMA JO - JAMA VL - 263 IS - 24 N2 - Outbreaks of acute hepatitis occurred in Huitzililla and Telixtac, two rural villages 70 miles south of Mexico City, Mexico, in late 1986. The first outbreak began in Huitzililla in June of that year, 1 month after the start of the rainy season. A census revealed 94 icteric case subjects, for an attack rate of 5%; two women died. Attack rates were higher for persons older than 15 years (10%) than for younger persons. A case-control study showed that illness was highly associated with water-related factors. The second outbreak began in August 1986 in Telixtac. There were 129 case subjects, for an attack rate of 6%; one woman died. Epidemiologic findings were similar to those in Huitzililla, except that most disease transmission was not linked to unsafe water sources. None of 62 case subjects in Huitzililla and only 2 of 53 case subjects in Telixtac tested had serological evidence for recent infection with hepatitis A or B. Two of eight stool samples from Huitzililla and one of the eight stool samples from Telixtac were positive by immune electron microscopy for 32- to 34-nm viruslike particles similar to those seen in cases of enterically transmitted non-A, non-B hepatitis from Asia. To our knowledge, these investigations document for the first time the epidemic transmission of enterically transmitted non-A, non-B hepatitis virus in the Americas. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/2112204/Epidemic_transmission_of_enterically_transmitted_non_A_non_B_hepatitis_in_Mexico_1986_1987_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/263/pg/3281 DB - PRIME DP - Unbound Medicine ER -