Tags

Type your tag names separated by a space and hit enter

Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma.
Respiration. 2011; 81(6):469-75.R

Abstract

BACKGROUND

Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied.

OBJECTIVE

To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma.

METHODS

We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV(1)), FEV(1) % predicted, and FEV(1)/forced vital capacity (FVC), and serum total IgE concentration.

RESULTS

Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV(1) % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV(1) (in liters), FEV(1) % predicted, and FEV(1)/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV(1) <75% predicted and 0.44 (0.20-0.95) for FEV(1)/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE.

CONCLUSIONS

Vitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function.

Authors+Show Affiliations

Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21124013

Citation

Li, Fei, et al. "Vitamin D Deficiency Is Associated With Decreased Lung Function in Chinese Adults With Asthma." Respiration; International Review of Thoracic Diseases, vol. 81, no. 6, 2011, pp. 469-75.
Li F, Peng M, Jiang L, et al. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration. 2011;81(6):469-75.
Li, F., Peng, M., Jiang, L., Sun, Q., Zhang, K., Lian, F., Litonjua, A. A., Gao, J., & Gao, X. (2011). Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Respiration; International Review of Thoracic Diseases, 81(6), 469-75. https://doi.org/10.1159/000322008
Li F, et al. Vitamin D Deficiency Is Associated With Decreased Lung Function in Chinese Adults With Asthma. Respiration. 2011;81(6):469-75. PubMed PMID: 21124013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. AU - Li,Fei, AU - Peng,Min, AU - Jiang,Lei, AU - Sun,Qi, AU - Zhang,Kui, AU - Lian,Fuzhi, AU - Litonjua,Augusto A, AU - Gao,Jinming, AU - Gao,Xiang, Y1 - 2010/12/01/ PY - 2010/05/24/received PY - 2010/10/11/accepted PY - 2010/12/3/entrez PY - 2010/12/3/pubmed PY - 2011/9/17/medline SP - 469 EP - 75 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 81 IS - 6 N2 - BACKGROUND: Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. OBJECTIVE: To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. METHODS: We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV(1)), FEV(1) % predicted, and FEV(1)/forced vital capacity (FVC), and serum total IgE concentration. RESULTS: Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV(1) % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV(1) (in liters), FEV(1) % predicted, and FEV(1)/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV(1) <75% predicted and 0.44 (0.20-0.95) for FEV(1)/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE. CONCLUSIONS: Vitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/21124013/Vitamin_D_deficiency_is_associated_with_decreased_lung_function_in_Chinese_adults_with_asthma_ L2 - https://www.karger.com?DOI=10.1159/000322008 DB - PRIME DP - Unbound Medicine ER -