Citation
de Graaf, Fleur R., et al. "Usefulness of Hypertriglyceridemic Waist Phenotype in Type 2 Diabetes Mellitus to Predict the Presence of Coronary Artery Disease as Assessed By Computed Tomographic Coronary Angiography." The American Journal of Cardiology, vol. 106, no. 12, 2010, pp. 1747-53.
de Graaf FR, Schuijf JD, Scholte AJ, et al. Usefulness of hypertriglyceridemic waist phenotype in type 2 diabetes mellitus to predict the presence of coronary artery disease as assessed by computed tomographic coronary angiography. Am J Cardiol. 2010;106(12):1747-53.
de Graaf, F. R., Schuijf, J. D., Scholte, A. J., Djaberi, R., van Velzen, J. E., Roos, C. J., Kroft, L. J., de Roos, A., van der Wall, E. E., Wouter Jukema, J., Després, J. P., & Bax, J. J. (2010). Usefulness of hypertriglyceridemic waist phenotype in type 2 diabetes mellitus to predict the presence of coronary artery disease as assessed by computed tomographic coronary angiography. The American Journal of Cardiology, 106(12), 1747-53. https://doi.org/10.1016/j.amjcard.2010.08.015
de Graaf FR, et al. Usefulness of Hypertriglyceridemic Waist Phenotype in Type 2 Diabetes Mellitus to Predict the Presence of Coronary Artery Disease as Assessed By Computed Tomographic Coronary Angiography. Am J Cardiol. 2010 Dec 15;106(12):1747-53. PubMed PMID: 21126619.
TY - JOUR
T1 - Usefulness of hypertriglyceridemic waist phenotype in type 2 diabetes mellitus to predict the presence of coronary artery disease as assessed by computed tomographic coronary angiography.
AU - de Graaf,Fleur R,
AU - Schuijf,Joanne D,
AU - Scholte,Arthur J,
AU - Djaberi,Roxana,
AU - van Velzen,Joella E,
AU - Roos,Cornelis J,
AU - Kroft,Lucia J,
AU - de Roos,Albert,
AU - van der Wall,Ernst E,
AU - Wouter Jukema,J,
AU - Després,Jean-Pierre,
AU - Bax,Jeroen J,
Y1 - 2010/10/26/
PY - 2010/06/10/received
PY - 2010/08/11/revised
PY - 2010/08/11/accepted
PY - 2010/12/4/entrez
PY - 2010/12/4/pubmed
PY - 2011/2/1/medline
SP - 1747
EP - 53
JF - The American journal of cardiology
JO - Am J Cardiol
VL - 106
IS - 12
N2 - The present study tested whether in patients with type 2 diabetes mellitus (DM) the combination of increased waist circumference and increased plasma triglyceride (TG) levels can predict the presence of coronary artery disease (CAD) as assessed by multidetector computed tomographic coronary angiography (CTA). In 202 patients with type 2 DM who were clinically referred for CTA, waist circumference and TG levels were measured. Patients were divided into 4 groups according to waist circumference measurements and TG levels. Increased waist circumference and TG levels (n = 61, 31%) indicated the presence of the hypertriglyceridemic waist phenotype. Patients with low waist circumference and TG (n = 49, 24%) were considered the reference group. Physical examination and blood measurements were performed. CTA was used to determine presence and severity of CAD. In addition, plaque type was evaluated. Plasma cholesterol levels were significantly increased in the group with increased TG levels and waist circumference, whereas high-density lipoprotein cholesterol was significantly lower than in the reference group. There was a significant increase in the presence of any CAD (odds ratio 3.3, confidence interval 1.31 to 8.13, p <0.05) and obstructive CAD (≥50%, odds ratio 2.9, confidence interval 1.16 to 7.28, p <0.05) in the group with increased TG level and waist circumference. In addition, a significantly larger number of noncalcified and mixed plaques was observed. In conclusion, in patients with type 2 DM, presence of the hypertriglyceridemic waist phenotype translated into a deteriorated blood lipid profile and more extensive CAD on CTA. Accordingly, the hypertriglyceridemic waist phenotype may serve as a practical clinical biomarker to improve risk stratification in patients with type 2 DM.
SN - 1879-1913
UR - https://www.unboundmedicine.com/medline/citation/21126619/Usefulness_of_hypertriglyceridemic_waist_phenotype_in_type_2_diabetes_mellitus_to_predict_the_presence_of_coronary_artery_disease_as_assessed_by_computed_tomographic_coronary_angiography_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(10)01620-6
DB - PRIME
DP - Unbound Medicine
ER -