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Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study.
J Hepatol. 2011 Apr; 54(4):760-4.JH

Abstract

BACKGROUND & AIMS

Alcoholic hepatitis is an acute life- and health-threatening disease that may be increasingly frequent. However, accurate and representative data on time trends in its incidence and prognosis are not available. This study aims to provide nationwide population-based estimates of alcoholic hepatitis incidence and mortality in Denmark, 1999-2008.

METHODS

We identified, from the Danish National Registry of Patients, all patients with a first-time discharge diagnosis of alcoholic hepatitis from 1999 and through 2008. We also ascertained whether patients had cirrhosis. We computed the annual incidence rates as well as 28-, 84-day, 5-year, and 10-year mortality rates.

RESULTS

We found 1951 patients with alcoholic hepatitis, 63% men. During the study decade, the annual incidence rate in the Danish population rose from 37 to 46 per 10(6) for men and from 24 to 34 per 10(6) for women. The steepest increase was observed among middle-aged women. The 28-day mortality rate rose from 12% to 15%, and the 84-day mortality rate rose from 14% to 24%, similarly for men and women. The increase in short-term mortality was attributable to increasing patient age and prevalence of cirrhosis. The 5-year mortality was 56% overall, 47% without cirrhosis, and 69% with cirrhosis.

CONCLUSIONS

The incidence of alcoholic hepatitis in Denmark has increased during the recent decade. The patients are older at diagnosis and more have cirrhosis, resulting in worse short-term prognosis. The long-term prognosis is grave, especially for patients with cirrhosis. The increase in incidence mirrors changes in alcohol consumption in Denmark.

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Authors+Show Affiliations

Sandahl TD
Department of Medicine V, Aarhus University Hospital, Denmark. Thomas.Damgaard.Sandahl@ki.au.dk
Jepsen P
No affiliation info available
Thomsen KL
No affiliation info available
Vilstrup H
No affiliation info available

MeSH

AdultAge FactorsAgedAged, 80 and overCohort StudiesDenmarkFemaleHepatitis, AlcoholicHumansIncidenceLiver Cirrhosis, AlcoholicMaleMiddle AgedRegistriesSex FactorsTime FactorsYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21126790

Citation

Sandahl, Thomas Damgaard, et al. "Incidence and Mortality of Alcoholic Hepatitis in Denmark 1999-2008: a Nationwide Population Based Cohort Study." Journal of Hepatology, vol. 54, no. 4, 2011, pp. 760-4.
Sandahl TD, Jepsen P, Thomsen KL, et al. Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. J Hepatol. 2011;54(4):760-4.
Sandahl, T. D., Jepsen, P., Thomsen, K. L., & Vilstrup, H. (2011). Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. Journal of Hepatology, 54(4), 760-4. https://doi.org/10.1016/j.jhep.2010.07.016
Sandahl TD, et al. Incidence and Mortality of Alcoholic Hepatitis in Denmark 1999-2008: a Nationwide Population Based Cohort Study. J Hepatol. 2011;54(4):760-4. PubMed PMID: 21126790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and mortality of alcoholic hepatitis in Denmark 1999-2008: a nationwide population based cohort study. AU - Sandahl,Thomas Damgaard, AU - Jepsen,Peter, AU - Thomsen,Karen Louise, AU - Vilstrup,Hendrik, Y1 - 2010/09/19/ PY - 2010/02/04/received PY - 2010/06/30/revised PY - 2010/07/26/accepted PY - 2010/12/4/entrez PY - 2010/12/4/pubmed PY - 2011/7/16/medline SP - 760 EP - 4 JF - Journal of hepatology JO - J Hepatol VL - 54 IS - 4 N2 - BACKGROUND & AIMS: Alcoholic hepatitis is an acute life- and health-threatening disease that may be increasingly frequent. However, accurate and representative data on time trends in its incidence and prognosis are not available. This study aims to provide nationwide population-based estimates of alcoholic hepatitis incidence and mortality in Denmark, 1999-2008. METHODS: We identified, from the Danish National Registry of Patients, all patients with a first-time discharge diagnosis of alcoholic hepatitis from 1999 and through 2008. We also ascertained whether patients had cirrhosis. We computed the annual incidence rates as well as 28-, 84-day, 5-year, and 10-year mortality rates. RESULTS: We found 1951 patients with alcoholic hepatitis, 63% men. During the study decade, the annual incidence rate in the Danish population rose from 37 to 46 per 10(6) for men and from 24 to 34 per 10(6) for women. The steepest increase was observed among middle-aged women. The 28-day mortality rate rose from 12% to 15%, and the 84-day mortality rate rose from 14% to 24%, similarly for men and women. The increase in short-term mortality was attributable to increasing patient age and prevalence of cirrhosis. The 5-year mortality was 56% overall, 47% without cirrhosis, and 69% with cirrhosis. CONCLUSIONS: The incidence of alcoholic hepatitis in Denmark has increased during the recent decade. The patients are older at diagnosis and more have cirrhosis, resulting in worse short-term prognosis. The long-term prognosis is grave, especially for patients with cirrhosis. The increase in incidence mirrors changes in alcohol consumption in Denmark. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/21126790/Incidence_and_mortality_of_alcoholic_hepatitis_in_Denmark_1999_2008:_a_nationwide_population_based_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(10)00804-4 DB - PRIME DP - Unbound Medicine ER -