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A bacterium that can grow by using arsenic instead of phosphorus.
Science. 2011 Jun 03; 332(6034):1163-6.Sci

Abstract

Life is mostly composed of the elements carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus. Although these six elements make up nucleic acids, proteins, and lipids and thus the bulk of living matter, it is theoretically possible that some other elements in the periodic table could serve the same functions. Here, we describe a bacterium, strain GFAJ-1 of the Halomonadaceae, isolated from Mono Lake, California, that is able to substitute arsenic for phosphorus to sustain its growth. Our data show evidence for arsenate in macromolecules that normally contain phosphate, most notably nucleic acids and proteins. Exchange of one of the major bio-elements may have profound evolutionary and geochemical importance.

Authors+Show Affiliations

NASA Astrobiology Institute, USA. felisawolfesimon@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21127214

Citation

Wolfe-Simon, Felisa, et al. "A Bacterium That Can Grow By Using Arsenic Instead of Phosphorus." Science (New York, N.Y.), vol. 332, no. 6034, 2011, pp. 1163-6.
Wolfe-Simon F, Switzer Blum J, Kulp TR, et al. A bacterium that can grow by using arsenic instead of phosphorus. Science. 2011;332(6034):1163-6.
Wolfe-Simon, F., Switzer Blum, J., Kulp, T. R., Gordon, G. W., Hoeft, S. E., Pett-Ridge, J., Stolz, J. F., Webb, S. M., Weber, P. K., Davies, P. C., Anbar, A. D., & Oremland, R. S. (2011). A bacterium that can grow by using arsenic instead of phosphorus. Science (New York, N.Y.), 332(6034), 1163-6. https://doi.org/10.1126/science.1197258
Wolfe-Simon F, et al. A Bacterium That Can Grow By Using Arsenic Instead of Phosphorus. Science. 2011 Jun 3;332(6034):1163-6. PubMed PMID: 21127214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A bacterium that can grow by using arsenic instead of phosphorus. AU - Wolfe-Simon,Felisa, AU - Switzer Blum,Jodi, AU - Kulp,Thomas R, AU - Gordon,Gwyneth W, AU - Hoeft,Shelley E, AU - Pett-Ridge,Jennifer, AU - Stolz,John F, AU - Webb,Samuel M, AU - Weber,Peter K, AU - Davies,Paul C W, AU - Anbar,Ariel D, AU - Oremland,Ronald S, Y1 - 2010/12/02/ PY - 2010/12/4/entrez PY - 2010/12/4/pubmed PY - 2011/6/22/medline SP - 1163 EP - 6 JF - Science (New York, N.Y.) JO - Science VL - 332 IS - 6034 N2 - Life is mostly composed of the elements carbon, hydrogen, nitrogen, oxygen, sulfur, and phosphorus. Although these six elements make up nucleic acids, proteins, and lipids and thus the bulk of living matter, it is theoretically possible that some other elements in the periodic table could serve the same functions. Here, we describe a bacterium, strain GFAJ-1 of the Halomonadaceae, isolated from Mono Lake, California, that is able to substitute arsenic for phosphorus to sustain its growth. Our data show evidence for arsenate in macromolecules that normally contain phosphate, most notably nucleic acids and proteins. Exchange of one of the major bio-elements may have profound evolutionary and geochemical importance. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/21127214/A_bacterium_that_can_grow_by_using_arsenic_instead_of_phosphorus_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=21127214 DB - PRIME DP - Unbound Medicine ER -