Tags

Type your tag names separated by a space and hit enter

Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica.
J Eur Acad Dermatol Venereol. 2011 Aug; 25(8):973-7.JE

Abstract

BACKGROUND

Cutaneous leishmaniasis (CL) is endemic in Israel, and in the past, has been attributed almost exclusively to Leishmania major. Over the last decade or so, an increase in Leishmania tropica (L. tropica) infections has occurred in several regions of Israel. Topical treatment of Old World CL is usually the rule, however, in some cases systemic treatment is indicated. Liposomal amphotericin B (L-AmB) is efficacious and safe for treating visceral leishmaniasis but its role in treating various forms of CL is yet to be defined. In this study, we summarize the efficacy and safety of L-AmB treatment in a series of Israeli patients with L. tropica infection.

METHODS

Cases of PCR-proven CL caused by L. tropica were treated in an outpatient setting. Treatment schedule consisted of five consecutive days of 3 mg/kg L-AmB, followed by a sixth dose on day 10.

RESULTS

Thirteen consecutive patients (11 men, two women), received L-AmB. Mean age was 15.3 years; of the 13 patients, 85% had facial lesions. Six had previously failed intralesional sodium stibogluconate treatment and four had failed topical paromomycin treatment. Eleven of 13 patients (84%) achieved complete clinical cure within 2 months. Mean follow-up of 11 months revealed no relapses. Side effects were mild and none terminated treatment prematurely.

LIMITATIONS

A non-randomized study, with a small number of patients.

CONCLUSION

Liposomal amphotericin B treatment for L. tropica is effective, well tolerated and cost beneficial in countries where cost of hospital-care is significant.

Authors+Show Affiliations

Department of Dermatology, Chaim Sheba Medical Center, Tel Hashomer, The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21129042

Citation

Solomon, M, et al. "Liposomal Amphotericin B Treatment of Cutaneous Leishmaniasis Due to Leishmania Tropica." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 25, no. 8, 2011, pp. 973-7.
Solomon M, Pavlotsky F, Leshem E, et al. Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica. J Eur Acad Dermatol Venereol. 2011;25(8):973-7.
Solomon, M., Pavlotsky, F., Leshem, E., Ephros, M., Trau, H., & Schwartz, E. (2011). Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica. Journal of the European Academy of Dermatology and Venereology : JEADV, 25(8), 973-7. https://doi.org/10.1111/j.1468-3083.2010.03908.x
Solomon M, et al. Liposomal Amphotericin B Treatment of Cutaneous Leishmaniasis Due to Leishmania Tropica. J Eur Acad Dermatol Venereol. 2011;25(8):973-7. PubMed PMID: 21129042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica. AU - Solomon,M, AU - Pavlotsky,F, AU - Leshem,E, AU - Ephros,M, AU - Trau,H, AU - Schwartz,E, Y1 - 2010/12/05/ PY - 2010/12/7/entrez PY - 2010/12/7/pubmed PY - 2011/12/29/medline SP - 973 EP - 7 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 25 IS - 8 N2 - BACKGROUND: Cutaneous leishmaniasis (CL) is endemic in Israel, and in the past, has been attributed almost exclusively to Leishmania major. Over the last decade or so, an increase in Leishmania tropica (L. tropica) infections has occurred in several regions of Israel. Topical treatment of Old World CL is usually the rule, however, in some cases systemic treatment is indicated. Liposomal amphotericin B (L-AmB) is efficacious and safe for treating visceral leishmaniasis but its role in treating various forms of CL is yet to be defined. In this study, we summarize the efficacy and safety of L-AmB treatment in a series of Israeli patients with L. tropica infection. METHODS: Cases of PCR-proven CL caused by L. tropica were treated in an outpatient setting. Treatment schedule consisted of five consecutive days of 3 mg/kg L-AmB, followed by a sixth dose on day 10. RESULTS: Thirteen consecutive patients (11 men, two women), received L-AmB. Mean age was 15.3 years; of the 13 patients, 85% had facial lesions. Six had previously failed intralesional sodium stibogluconate treatment and four had failed topical paromomycin treatment. Eleven of 13 patients (84%) achieved complete clinical cure within 2 months. Mean follow-up of 11 months revealed no relapses. Side effects were mild and none terminated treatment prematurely. LIMITATIONS: A non-randomized study, with a small number of patients. CONCLUSION: Liposomal amphotericin B treatment for L. tropica is effective, well tolerated and cost beneficial in countries where cost of hospital-care is significant. SN - 1468-3083 UR - https://www.unboundmedicine.com/medline/citation/21129042/Liposomal_amphotericin_B_treatment_of_cutaneous_leishmaniasis_due_to_Leishmania_tropica_ L2 - https://doi.org/10.1111/j.1468-3083.2010.03908.x DB - PRIME DP - Unbound Medicine ER -