Tags

Type your tag names separated by a space and hit enter

Ontogeny and neural substrates of the context preexposure facilitation effect.
Neurobiol Learn Mem. 2011 Feb; 95(2):190-8.NL

Abstract

Contextual fear conditioning emerges around post-natal day (PD) 23 in the rat. This is thought to reflect hippocampus-dependent conjunctive learning, which binds the individual features of the context into a unified representation (Rudy, 1993). However, context conditioning can also be supported by hippocampus-independent, feature-based simple associations (Rudy, 2009) and these may operate at PD 23-24 (Pugh & Rudy, 1996). To address this issue, we studied the ontogeny of a variant of contextual fear conditioning, termed the context-preexposure-facilitation-effect (CPFE), in which exposure to context and (immediate) foot shock occur on successive occasions. This variant requires conjunctive as opposed to feature-based simple associations (Rudy, 2009). We tested PD 17, 24, and 31 rats on the CPFE vs. conventional context conditioning (Exp. 1) and on the CPFE with stronger reinforcement (Exp. 2). The CPFE emerged on PD 24 regardless of reinforcer strength and in parallel with context conditioning. Infusions of the NMDA-receptor antagonist, MK-801, into the dorsal hippocampus just before pre-exposure on PD 24 eliminated the CPFE, whereas infusions occurring after pre-exposure had no effect (Exp. 3). These findings demonstrate a role of hippocampal NMDA receptors in the CPFE as early as PD 24 and implicate conjunctive learning mechanisms in the ontogeny of contextual fear conditioning.

Links

PMC Free PDF
PMC Free Full Text
Publisher Full Text
Aggregator Full Text

Authors+Show Affiliations

Schiffino FL
The University of Delaware, United States.
Murawski NJ
No affiliation info available
Rosen JB
No affiliation info available
Stanton ME
No affiliation info available

MeSH

AmygdalaAnalysis of VarianceAnimalsConditioning, ClassicalDizocilpine MaleateElectroshockExcitatory Amino Acid AntagonistsFearFemaleHippocampusMaleRatsRats, Long-EvansReceptors, N-Methyl-D-AspartateReinforcement, Psychology

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21129493

Citation

Schiffino, Felipe L., et al. "Ontogeny and Neural Substrates of the Context Preexposure Facilitation Effect." Neurobiology of Learning and Memory, vol. 95, no. 2, 2011, pp. 190-8.
Schiffino FL, Murawski NJ, Rosen JB, et al. Ontogeny and neural substrates of the context preexposure facilitation effect. Neurobiol Learn Mem. 2011;95(2):190-8.
Schiffino, F. L., Murawski, N. J., Rosen, J. B., & Stanton, M. E. (2011). Ontogeny and neural substrates of the context preexposure facilitation effect. Neurobiology of Learning and Memory, 95(2), 190-8. https://doi.org/10.1016/j.nlm.2010.11.011
Schiffino FL, et al. Ontogeny and Neural Substrates of the Context Preexposure Facilitation Effect. Neurobiol Learn Mem. 2011;95(2):190-8. PubMed PMID: 21129493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ontogeny and neural substrates of the context preexposure facilitation effect. AU - Schiffino,Felipe L, AU - Murawski,Nathen J, AU - Rosen,Jeffrey B, AU - Stanton,Mark E, Y1 - 2010/12/01/ PY - 2010/07/24/received PY - 2010/11/13/revised PY - 2010/11/20/accepted PY - 2010/12/7/entrez PY - 2010/12/7/pubmed PY - 2011/7/21/medline SP - 190 EP - 8 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 95 IS - 2 N2 - Contextual fear conditioning emerges around post-natal day (PD) 23 in the rat. This is thought to reflect hippocampus-dependent conjunctive learning, which binds the individual features of the context into a unified representation (Rudy, 1993). However, context conditioning can also be supported by hippocampus-independent, feature-based simple associations (Rudy, 2009) and these may operate at PD 23-24 (Pugh & Rudy, 1996). To address this issue, we studied the ontogeny of a variant of contextual fear conditioning, termed the context-preexposure-facilitation-effect (CPFE), in which exposure to context and (immediate) foot shock occur on successive occasions. This variant requires conjunctive as opposed to feature-based simple associations (Rudy, 2009). We tested PD 17, 24, and 31 rats on the CPFE vs. conventional context conditioning (Exp. 1) and on the CPFE with stronger reinforcement (Exp. 2). The CPFE emerged on PD 24 regardless of reinforcer strength and in parallel with context conditioning. Infusions of the NMDA-receptor antagonist, MK-801, into the dorsal hippocampus just before pre-exposure on PD 24 eliminated the CPFE, whereas infusions occurring after pre-exposure had no effect (Exp. 3). These findings demonstrate a role of hippocampal NMDA receptors in the CPFE as early as PD 24 and implicate conjunctive learning mechanisms in the ontogeny of contextual fear conditioning. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/21129493/Ontogeny_and_neural_substrates_of_the_context_preexposure_facilitation_effect_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(10)00197-8 DB - PRIME DP - Unbound Medicine ER -