Tags

Type your tag names separated by a space and hit enter

Detection of phentermine in hair samples from drug suspects.
Forensic Sci Int. 2011 Apr 15; 207(1-3):e5-7.FS

Abstract

Phentermine (PT) has been widely used as an anti-obesity drug. This drug has to be used with caution due to its close resemblance with amphetamines in its structure and toxicity profile. Recently, PT is in distribution by illegal modes and is found to be available through sources such as the internet, thus their misuse and/or abuse is threatening to be a serious social issue. In the present study, 32 cases of drug suspects were observed for PT abuse, detected using hair samples for drug analysis. PT and other amphetamines, such as methamphetamine (MA), amphetamine (AP), 3,4-methylenedioxyamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA), were extracted using 1% HCl in methanol for 20 h at 38°C. The extracts were derivatized with trifluoroacetic anhydride (TFAA) and analyzed using gas chromatography/mass spectrometry (GC/MS). Among the 32 cases of PT abuse, MA and its main metabolite, AP were identified in seven cases and MDMA and its main metabolite, MDA were detected in two other cases.

Authors+Show Affiliations

National Institute of Scientific Investigation, 331-1 Sinwol-7-dong, Yangcheon-gu, Seoul 158-707, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21129868

Citation

Lee, Sooyeun, et al. "Detection of Phentermine in Hair Samples From Drug Suspects." Forensic Science International, vol. 207, no. 1-3, 2011, pp. e5-7.
Lee S, Kim J, In S, et al. Detection of phentermine in hair samples from drug suspects. Forensic Sci Int. 2011;207(1-3):e5-7.
Lee, S., Kim, J., In, S., Choi, H., Chung, H., & Chung, K. H. (2011). Detection of phentermine in hair samples from drug suspects. Forensic Science International, 207(1-3), e5-7. https://doi.org/10.1016/j.forsciint.2010.11.004
Lee S, et al. Detection of Phentermine in Hair Samples From Drug Suspects. Forensic Sci Int. 2011 Apr 15;207(1-3):e5-7. PubMed PMID: 21129868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of phentermine in hair samples from drug suspects. AU - Lee,Sooyeun, AU - Kim,Jihyun, AU - In,Sanghwan, AU - Choi,Hwakyung, AU - Chung,Heesun, AU - Chung,Kyu Hyuck, Y1 - 2010/12/03/ PY - 2010/08/30/received PY - 2010/11/02/revised PY - 2010/11/05/accepted PY - 2010/12/7/entrez PY - 2010/12/7/pubmed PY - 2011/9/23/medline SP - e5 EP - 7 JF - Forensic science international JO - Forensic Sci Int VL - 207 IS - 1-3 N2 - Phentermine (PT) has been widely used as an anti-obesity drug. This drug has to be used with caution due to its close resemblance with amphetamines in its structure and toxicity profile. Recently, PT is in distribution by illegal modes and is found to be available through sources such as the internet, thus their misuse and/or abuse is threatening to be a serious social issue. In the present study, 32 cases of drug suspects were observed for PT abuse, detected using hair samples for drug analysis. PT and other amphetamines, such as methamphetamine (MA), amphetamine (AP), 3,4-methylenedioxyamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA), were extracted using 1% HCl in methanol for 20 h at 38°C. The extracts were derivatized with trifluoroacetic anhydride (TFAA) and analyzed using gas chromatography/mass spectrometry (GC/MS). Among the 32 cases of PT abuse, MA and its main metabolite, AP were identified in seven cases and MDMA and its main metabolite, MDA were detected in two other cases. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/21129868/Detection_of_phentermine_in_hair_samples_from_drug_suspects_ DB - PRIME DP - Unbound Medicine ER -