Tags

Type your tag names separated by a space and hit enter

Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes.
Med Sci Sports Exerc. 2011 Jul; 43(7):1207-13.MS

Abstract

PURPOSE

Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water loss by peripheral airways during hyperpnea is regarded as the initial trigger for EIB, the cascade of events that follows remains unclear. Our goal was to establish whether transient disruption of the airway epithelial barrier occurs after a short period of hyperpnea of dry air in athletes with EIB.

METHODS

Urinary concentration of the pneumoprotein Clara cell (CC16) was used as an assumed biomarker of lung epithelial cell damage or dysfunction. Samples were collected at baseline and for 90 min after an 8-min eucapnic voluntary hyperpnea (EVH) test in 50 female individuals (28 athletes and 22 untrained).

RESULTS

Nineteen subjects (10 athletes) demonstrated a sustained bronchoconstriction after EVH (mean±SE forced expiratory volume in the first second (FEV1) fall from baseline=23.4%±2.6%). The remaining subjects had a negative challenge result with an FEV1 fall of 5.9%±0.6%. An increase (P<0.001) in urinary CC16 concentration was noticed after EVH in all but one subject, with no group difference (median CC16 increase before to after challenge: athletes EVH 0.083 ng·μmol, athletes EVH 0.223 ng·μmol, untrained EVH 0.074 ng·μmol, untrained EVH 0.571 ng·μmol; P>0.05).

CONCLUSIONS

Urinary levels of CC16 are increased after EVH in all individuals (trained and untrained, with and without EIB) suggestive of dehydration-induced perturbation of the distal respiratory epithelium during episodes of hyperventilation.

Authors+Show Affiliations

School of Medical Sciences, Department of Occupational Medicine, University of Aberdeen, Aberdeen, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21131866

Citation

Bolger, Claire, et al. "Hyperpnea-induced Bronchoconstriction and Urinary CC16 Levels in Athletes." Medicine and Science in Sports and Exercise, vol. 43, no. 7, 2011, pp. 1207-13.
Bolger C, Tufvesson E, Sue-Chu M, et al. Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. Med Sci Sports Exerc. 2011;43(7):1207-13.
Bolger, C., Tufvesson, E., Sue-Chu, M., Devereux, G., Ayres, J. G., Bjermer, L., & Kippelen, P. (2011). Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. Medicine and Science in Sports and Exercise, 43(7), 1207-13. https://doi.org/10.1249/MSS.0b013e31820750d8
Bolger C, et al. Hyperpnea-induced Bronchoconstriction and Urinary CC16 Levels in Athletes. Med Sci Sports Exerc. 2011;43(7):1207-13. PubMed PMID: 21131866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes. AU - Bolger,Claire, AU - Tufvesson,Ellen, AU - Sue-Chu,Malcolm, AU - Devereux,Graham, AU - Ayres,Jon G, AU - Bjermer,Leif, AU - Kippelen,Pascale, PY - 2010/12/7/entrez PY - 2010/12/7/pubmed PY - 2011/10/29/medline SP - 1207 EP - 13 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 43 IS - 7 N2 - PURPOSE: Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes. Although excessive water loss by peripheral airways during hyperpnea is regarded as the initial trigger for EIB, the cascade of events that follows remains unclear. Our goal was to establish whether transient disruption of the airway epithelial barrier occurs after a short period of hyperpnea of dry air in athletes with EIB. METHODS: Urinary concentration of the pneumoprotein Clara cell (CC16) was used as an assumed biomarker of lung epithelial cell damage or dysfunction. Samples were collected at baseline and for 90 min after an 8-min eucapnic voluntary hyperpnea (EVH) test in 50 female individuals (28 athletes and 22 untrained). RESULTS: Nineteen subjects (10 athletes) demonstrated a sustained bronchoconstriction after EVH (mean±SE forced expiratory volume in the first second (FEV1) fall from baseline=23.4%±2.6%). The remaining subjects had a negative challenge result with an FEV1 fall of 5.9%±0.6%. An increase (P<0.001) in urinary CC16 concentration was noticed after EVH in all but one subject, with no group difference (median CC16 increase before to after challenge: athletes EVH 0.083 ng·μmol, athletes EVH 0.223 ng·μmol, untrained EVH 0.074 ng·μmol, untrained EVH 0.571 ng·μmol; P>0.05). CONCLUSIONS: Urinary levels of CC16 are increased after EVH in all individuals (trained and untrained, with and without EIB) suggestive of dehydration-induced perturbation of the distal respiratory epithelium during episodes of hyperventilation. SN - 1530-0315 UR - https://www.unboundmedicine.com/medline/citation/21131866/Hyperpnea_induced_bronchoconstriction_and_urinary_CC16_levels_in_athletes_ L2 - http://dx.doi.org/10.1249/MSS.0b013e31820750d8 DB - PRIME DP - Unbound Medicine ER -