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Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults.
Lipids Health Dis. 2010 Dec 07; 9:138.LH

Abstract

BACKGROUND

The aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults.

METHODS

This cross-sectional study included 614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years. The study sample were 1,042 (74.8%) non-obese (BMI < 25.0 kg/m²) and 351 (25.2%) overweight (BMI ≥ 25 kg/m²) subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of these serum markers.

RESULTS

In non-obese subjects, the best marker of insulin resistance was low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio of 0.74 (95% confidence interval (CI), 0.66-0.80). The HDL-C, triglyceride (TG)/HDL-C ratio, and non-HDL-C also discriminated insulin resistance, as the values for AUC were 0.31 (95% CI, 0.24-0.38), 0.69 (95% CI, 0.62-0.75) and 0.69 (95% CI, 0.62-0.75), respectively. In overweight subjects, the AUC for TG and TG/HDL-C ratio were 0.64 (0.58-0.71) and 0.64 (0.57-0.70), respectively. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: TG/HDL-C ratio of ≥ 1.50 and LDL-C/HDL-C ratio of ≥ 2.14 in non-obese subjects, and ≥ 2.20, ≥ 2.25 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for LDL-C/HDL-C ratio.

CONCLUSION

In non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance.

Authors+Show Affiliations

Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan. rykawamo@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21134293

Citation

Kawamoto, Ryuichi, et al. "Low-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio Is the Best Surrogate Marker for Insulin Resistance in Non-obese Japanese Adults." Lipids in Health and Disease, vol. 9, 2010, p. 138.
Kawamoto R, Tabara Y, Kohara K, et al. Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults. Lipids Health Dis. 2010;9:138.
Kawamoto, R., Tabara, Y., Kohara, K., Miki, T., Kusunoki, T., Takayama, S., Abe, M., Katoh, T., & Ohtsuka, N. (2010). Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults. Lipids in Health and Disease, 9, 138. https://doi.org/10.1186/1476-511X-9-138
Kawamoto R, et al. Low-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio Is the Best Surrogate Marker for Insulin Resistance in Non-obese Japanese Adults. Lipids Health Dis. 2010 Dec 7;9:138. PubMed PMID: 21134293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults. AU - Kawamoto,Ryuichi, AU - Tabara,Yasuharu, AU - Kohara,Katsuhiko, AU - Miki,Tetsuro, AU - Kusunoki,Tomo, AU - Takayama,Shuzo, AU - Abe,Masanori, AU - Katoh,Tateaki, AU - Ohtsuka,Nobuyuki, Y1 - 2010/12/07/ PY - 2010/10/07/received PY - 2010/12/07/accepted PY - 2010/12/8/entrez PY - 2010/12/8/pubmed PY - 2011/7/1/medline SP - 138 EP - 138 JF - Lipids in health and disease JO - Lipids Health Dis VL - 9 N2 - BACKGROUND: The aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults. METHODS: This cross-sectional study included 614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years. The study sample were 1,042 (74.8%) non-obese (BMI < 25.0 kg/m²) and 351 (25.2%) overweight (BMI ≥ 25 kg/m²) subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of these serum markers. RESULTS: In non-obese subjects, the best marker of insulin resistance was low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio of 0.74 (95% confidence interval (CI), 0.66-0.80). The HDL-C, triglyceride (TG)/HDL-C ratio, and non-HDL-C also discriminated insulin resistance, as the values for AUC were 0.31 (95% CI, 0.24-0.38), 0.69 (95% CI, 0.62-0.75) and 0.69 (95% CI, 0.62-0.75), respectively. In overweight subjects, the AUC for TG and TG/HDL-C ratio were 0.64 (0.58-0.71) and 0.64 (0.57-0.70), respectively. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: TG/HDL-C ratio of ≥ 1.50 and LDL-C/HDL-C ratio of ≥ 2.14 in non-obese subjects, and ≥ 2.20, ≥ 2.25 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for LDL-C/HDL-C ratio. CONCLUSION: In non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/21134293/Low_density_lipoprotein_cholesterol_to_high_density_lipoprotein_cholesterol_ratio_is_the_best_surrogate_marker_for_insulin_resistance_in_non_obese_Japanese_adults_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-138 DB - PRIME DP - Unbound Medicine ER -