Tags

Type your tag names separated by a space and hit enter

Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes.
Br J Nutr. 2011 Feb; 105(4):584-92.BJ

Abstract

The role of dietary cholesterol in people with diabetes has been little studied. We investigated the effect of a hypoenergetic high-protein high-cholesterol (HPHchol) diet compared to a similar amount of animal protein (high-protein low-cholesterol, HPLchol) on plasma lipids, glycaemic control and cardiovascular risk markers in individuals with type 2 diabetes. A total of sixty-five participants with type 2 diabetes or impaired glucose tolerance (age 54·4 (sd 8·2) years; BMI 34·1 (sd 4·8) kg/m2; LDL-cholesterol (LDL-C) 2·67 (sd 0·10) mmol/l) were randomised to either HPHchol or HPLchol. Both hypoenergetic dietary interventions (6-7 MJ; 1·4-1·7 Mcal) and total carbohydrate:protein:fat ratio of 40:30:30 % were similar but differed in cholesterol content (HPHchol, 590 mg cholesterol; HPLchol, 213 mg cholesterol). HPHchol participants consumed two eggs per d, whereas HPHchol participants replaced the eggs with 100 g of lean animal protein. After 12 weeks, weight loss was 6·0 (sd 0·4) kg (P < 0·001). LDL-C and homocysteine remained unchanged. All the subjects reduced total cholesterol (- 0·3 (sd 0·1) mmol/l, P < 0·001), TAG (- 0·4 (sd 0·1) mmol/l, P < 0·001), non-HDL-cholesterol (HDL-C, - 0·4 (sd 0·1) mmol/l, P < 0·001), apo-B (- 0·04 (sd 0·02) mmol/l, P < 0·01), HbA1c (- 0·6 (sd 0·1) %, P < 0·001), fasting blood glucose (- 0·5 (sd 0·2) mmol/l, P < 0·01), fasting insulin (- 1·7 (sd 0·7) mIU/l, P < 0·01), systolic blood pressure (- 7·6 (sd 1·7) mmHg, P < 0·001) and diastolic blood pressure (- 4·6 (sd 1·0) mmHg; P < 0·001). Significance was not altered by diet, sex, medication or amount of weight loss. HDL-C increased on HPHchol (+0·02 (sd 0·02) mmol/l) and decreased on HPLchol (- 0·07 (sd 0·03) mmol/l, P < 0·05). Plasma folate and lutein increased more on HPHchol (P < 0·05). These results suggest that a high-protein energy-restricted diet high in cholesterol from eggs improved glycaemic and lipid profiles, blood pressure and apo-B in individuals with type 2 diabetes.

Authors+Show Affiliations

Commonwealth Scientific and Industrial Research Organization (CSIRO), Food and Nutritional Sciences, Adelaide, SA 5000, Australia. karma.pearce@unisa.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21134328

Citation

Pearce, Karma L., et al. "Egg Consumption as Part of an Energy-restricted High-protein Diet Improves Blood Lipid and Blood Glucose Profiles in Individuals With Type 2 Diabetes." The British Journal of Nutrition, vol. 105, no. 4, 2011, pp. 584-92.
Pearce KL, Clifton PM, Noakes M. Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes. Br J Nutr. 2011;105(4):584-92.
Pearce, K. L., Clifton, P. M., & Noakes, M. (2011). Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes. The British Journal of Nutrition, 105(4), 584-92. https://doi.org/10.1017/S0007114510003983
Pearce KL, Clifton PM, Noakes M. Egg Consumption as Part of an Energy-restricted High-protein Diet Improves Blood Lipid and Blood Glucose Profiles in Individuals With Type 2 Diabetes. Br J Nutr. 2011;105(4):584-92. PubMed PMID: 21134328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes. AU - Pearce,Karma L, AU - Clifton,Peter M, AU - Noakes,Manny, Y1 - 2010/12/07/ PY - 2010/12/8/entrez PY - 2010/12/8/pubmed PY - 2011/3/15/medline SP - 584 EP - 92 JF - The British journal of nutrition JO - Br J Nutr VL - 105 IS - 4 N2 - The role of dietary cholesterol in people with diabetes has been little studied. We investigated the effect of a hypoenergetic high-protein high-cholesterol (HPHchol) diet compared to a similar amount of animal protein (high-protein low-cholesterol, HPLchol) on plasma lipids, glycaemic control and cardiovascular risk markers in individuals with type 2 diabetes. A total of sixty-five participants with type 2 diabetes or impaired glucose tolerance (age 54·4 (sd 8·2) years; BMI 34·1 (sd 4·8) kg/m2; LDL-cholesterol (LDL-C) 2·67 (sd 0·10) mmol/l) were randomised to either HPHchol or HPLchol. Both hypoenergetic dietary interventions (6-7 MJ; 1·4-1·7 Mcal) and total carbohydrate:protein:fat ratio of 40:30:30 % were similar but differed in cholesterol content (HPHchol, 590 mg cholesterol; HPLchol, 213 mg cholesterol). HPHchol participants consumed two eggs per d, whereas HPHchol participants replaced the eggs with 100 g of lean animal protein. After 12 weeks, weight loss was 6·0 (sd 0·4) kg (P < 0·001). LDL-C and homocysteine remained unchanged. All the subjects reduced total cholesterol (- 0·3 (sd 0·1) mmol/l, P < 0·001), TAG (- 0·4 (sd 0·1) mmol/l, P < 0·001), non-HDL-cholesterol (HDL-C, - 0·4 (sd 0·1) mmol/l, P < 0·001), apo-B (- 0·04 (sd 0·02) mmol/l, P < 0·01), HbA1c (- 0·6 (sd 0·1) %, P < 0·001), fasting blood glucose (- 0·5 (sd 0·2) mmol/l, P < 0·01), fasting insulin (- 1·7 (sd 0·7) mIU/l, P < 0·01), systolic blood pressure (- 7·6 (sd 1·7) mmHg, P < 0·001) and diastolic blood pressure (- 4·6 (sd 1·0) mmHg; P < 0·001). Significance was not altered by diet, sex, medication or amount of weight loss. HDL-C increased on HPHchol (+0·02 (sd 0·02) mmol/l) and decreased on HPLchol (- 0·07 (sd 0·03) mmol/l, P < 0·05). Plasma folate and lutein increased more on HPHchol (P < 0·05). These results suggest that a high-protein energy-restricted diet high in cholesterol from eggs improved glycaemic and lipid profiles, blood pressure and apo-B in individuals with type 2 diabetes. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21134328/Egg_consumption_as_part_of_an_energy_restricted_high_protein_diet_improves_blood_lipid_and_blood_glucose_profiles_in_individuals_with_type_2_diabetes_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510003983/type/journal_article DB - PRIME DP - Unbound Medicine ER -