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Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients.
Blood Purif. 2011; 31(1-3):33-40.BP

Abstract

AIM

To evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis (MHD) patients.

METHODS

Forty MHD patients with uncontrolled hyperphosphatemia were randomized to either low DPI with keto acid-supplemented (sLP) or normal DPI (NP) group for 8 weeks. After 8 weeks, the sLP group was shifted to NP for another 8 weeks. Low-protein diet (LPD) was individualized with total caloric intake 30-35 kcal/kg/day, protein intake of 0.8 g/kg/day and phosphate intake of 500 mg/day. Keto acids were supplied in a dosage of 12 pills per day. Calcium phosphorous metabolism index and nutritional index (serum albumin, total protein, somatometric measurements, 3-day diaries and Mini-Nutritional Assessment score) were recorded. C-reactive protein, CO(2) combining power and Kt/V were measured to evaluate the inflammation, metabolic acidosis and dialysis adequacy, respectively.

RESULTS

Serum phosphorus level and calcium-phosphate product were significantly decreased at the end of the first 8 weeks in the sLP group compared to the basal value and the NP group (p < 0.001). No difference was observed in C-reactive protein, Kt/V and nutritional index, while CO(2) combining power was significantly higher at week 8 in the sLP group (p < 0.001).

CONCLUSION

Short-term restriction of DPI supplemented with keto acids could decrease hyperphosphatemia and calcium-phosphate product, while keeping stable nutritional status among MHD patients.

Authors+Show Affiliations

Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21135547

Citation

Li, Haiming, et al. "Effect of Short-term Low-protein Diet Supplemented With Keto Acids On Hyperphosphatemia in Maintenance Hemodialysis Patients." Blood Purification, vol. 31, no. 1-3, 2011, pp. 33-40.
Li H, Long Q, Shao C, et al. Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients. Blood Purif. 2011;31(1-3):33-40.
Li, H., Long, Q., Shao, C., Fan, H., Yuan, L., Huang, B., Gu, Y., Lin, S., Hao, C., & Chen, J. (2011). Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients. Blood Purification, 31(1-3), 33-40. https://doi.org/10.1159/000321376
Li H, et al. Effect of Short-term Low-protein Diet Supplemented With Keto Acids On Hyperphosphatemia in Maintenance Hemodialysis Patients. Blood Purif. 2011;31(1-3):33-40. PubMed PMID: 21135547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of short-term low-protein diet supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis patients. AU - Li,Haiming, AU - Long,Quan, AU - Shao,Chunhai, AU - Fan,Hong, AU - Yuan,Li, AU - Huang,Bihong, AU - Gu,Yong, AU - Lin,Shanyan, AU - Hao,Chuanming, AU - Chen,Jing, Y1 - 2010/12/07/ PY - 2010/05/28/received PY - 2010/09/15/accepted PY - 2010/12/8/entrez PY - 2010/12/8/pubmed PY - 2011/5/3/medline SP - 33 EP - 40 JF - Blood purification JO - Blood Purif VL - 31 IS - 1-3 N2 - AIM: To evaluate the effects of short-term restriction of dietary protein intake (DPI) supplemented with keto acids on hyperphosphatemia in maintenance hemodialysis (MHD) patients. METHODS: Forty MHD patients with uncontrolled hyperphosphatemia were randomized to either low DPI with keto acid-supplemented (sLP) or normal DPI (NP) group for 8 weeks. After 8 weeks, the sLP group was shifted to NP for another 8 weeks. Low-protein diet (LPD) was individualized with total caloric intake 30-35 kcal/kg/day, protein intake of 0.8 g/kg/day and phosphate intake of 500 mg/day. Keto acids were supplied in a dosage of 12 pills per day. Calcium phosphorous metabolism index and nutritional index (serum albumin, total protein, somatometric measurements, 3-day diaries and Mini-Nutritional Assessment score) were recorded. C-reactive protein, CO(2) combining power and Kt/V were measured to evaluate the inflammation, metabolic acidosis and dialysis adequacy, respectively. RESULTS: Serum phosphorus level and calcium-phosphate product were significantly decreased at the end of the first 8 weeks in the sLP group compared to the basal value and the NP group (p < 0.001). No difference was observed in C-reactive protein, Kt/V and nutritional index, while CO(2) combining power was significantly higher at week 8 in the sLP group (p < 0.001). CONCLUSION: Short-term restriction of DPI supplemented with keto acids could decrease hyperphosphatemia and calcium-phosphate product, while keeping stable nutritional status among MHD patients. SN - 1421-9735 UR - https://www.unboundmedicine.com/medline/citation/21135547/Effect_of_short_term_low_protein_diet_supplemented_with_keto_acids_on_hyperphosphatemia_in_maintenance_hemodialysis_patients_ L2 - https://www.karger.com?DOI=10.1159/000321376 DB - PRIME DP - Unbound Medicine ER -