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Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias.
Dement Geriatr Cogn Disord 2011; 31(1):37-44DG

Abstract

BACKGROUND/AIMS

We determined cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ)(1-38), Aβ(1-40), Aβ(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20).

METHODS

Commercially available ELISA and electrochemiluminescence methods were applied.

RESULTS

High CSF p-tau and low ratios of Aβ(1-42)/Aβ(1-40) and Aβ(1-42)/Aβ(1-38), respectively, were specific for AD. CSF Aβ(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD.

CONCLUSION

This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations.

Authors+Show Affiliations

Department of Psychiatry, Psychotherapy and Addiction Medicine, Kliniken Essen-Mitte, University of Duisburg-Essen, Essen, Germany. m.bibl@kliniken-essen-mitte.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21135556

Citation

Bibl, Mirko, et al. "Cerebrospinal Fluid Tau, P-tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias." Dementia and Geriatric Cognitive Disorders, vol. 31, no. 1, 2011, pp. 37-44.
Bibl M, Mollenhauer B, Lewczuk P, et al. Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias. Dement Geriatr Cogn Disord. 2011;31(1):37-44.
Bibl, M., Mollenhauer, B., Lewczuk, P., Esselmann, H., Wolf, S., Otto, M., ... Wiltfang, J. (2011). Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias. Dementia and Geriatric Cognitive Disorders, 31(1), pp. 37-44. doi:10.1159/000322370.
Bibl M, et al. Cerebrospinal Fluid Tau, P-tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias. Dement Geriatr Cogn Disord. 2011;31(1):37-44. PubMed PMID: 21135556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias. AU - Bibl,Mirko, AU - Mollenhauer,Brit, AU - Lewczuk,Piotr, AU - Esselmann,Hermann, AU - Wolf,Stefanie, AU - Otto,Markus, AU - Kornhuber,Johannes, AU - Rüther,Eckart, AU - Wiltfang,Jens, Y1 - 2010/12/07/ PY - 2010/10/22/accepted PY - 2010/12/8/entrez PY - 2010/12/8/pubmed PY - 2011/5/20/medline SP - 37 EP - 44 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 31 IS - 1 N2 - BACKGROUND/AIMS: We determined cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ)(1-38), Aβ(1-40), Aβ(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20). METHODS: Commercially available ELISA and electrochemiluminescence methods were applied. RESULTS: High CSF p-tau and low ratios of Aβ(1-42)/Aβ(1-40) and Aβ(1-42)/Aβ(1-38), respectively, were specific for AD. CSF Aβ(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. CONCLUSION: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/21135556/Cerebrospinal_fluid_tau_p_tau_181_and_amyloid_β38/40/42_in_frontotemporal_dementias_and_primary_progressive_aphasias_ L2 - https://www.karger.com?DOI=10.1159/000322370 DB - PRIME DP - Unbound Medicine ER -