Citation
Poynton, Helen C., et al. "Differential Gene Expression in Daphnia Magna Suggests Distinct Modes of Action and Bioavailability for ZnO Nanoparticles and Zn Ions." Environmental Science & Technology, vol. 45, no. 2, 2011, pp. 762-8.
Poynton HC, Lazorchak JM, Impellitteri CA, et al. Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions. Environ Sci Technol. 2011;45(2):762-8.
Poynton, H. C., Lazorchak, J. M., Impellitteri, C. A., Smith, M. E., Rogers, K., Patra, M., Hammer, K. A., Allen, H. J., & Vulpe, C. D. (2011). Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions. Environmental Science & Technology, 45(2), 762-8. https://doi.org/10.1021/es102501z
Poynton HC, et al. Differential Gene Expression in Daphnia Magna Suggests Distinct Modes of Action and Bioavailability for ZnO Nanoparticles and Zn Ions. Environ Sci Technol. 2011 Jan 15;45(2):762-8. PubMed PMID: 21142172.
TY - JOUR
T1 - Differential gene expression in Daphnia magna suggests distinct modes of action and bioavailability for ZnO nanoparticles and Zn ions.
AU - Poynton,Helen C,
AU - Lazorchak,James M,
AU - Impellitteri,Christopher A,
AU - Smith,Mark E,
AU - Rogers,Kim,
AU - Patra,Manomita,
AU - Hammer,Katherine A,
AU - Allen,H Joel,
AU - Vulpe,Chris D,
Y1 - 2010/12/13/
PY - 2010/12/15/entrez
PY - 2010/12/15/pubmed
PY - 2011/3/30/medline
SP - 762
EP - 8
JF - Environmental science & technology
JO - Environ Sci Technol
VL - 45
IS - 2
N2 - Zinc oxide nanoparticles (ZnO NPs) are being rapidly developed for use in consumer products, wastewater treatment, and chemotherapy providing several possible routes for ZnO NP exposure to humans and aquatic organisms. Recent studies have shown that ZnO NPs undergo rapid dissolution to Zn(2+), but the relative contribution of Zn(2+) to ZnO NP bioavailability and toxicity is not clear. We show that a fraction of the ZnO NPs in suspension dissolves, and this fraction cannot account for the toxicity of the ZnO NP suspensions to Daphnia magna. Gene expression profiling of D. magna exposed to ZnO NPs or ZnSO(4) at sublethal concentrations revealed distinct modes of toxicity. There was also little overlap in gene expression between ZnO NPs and SiO(x) NPs, suggesting specificity for the ZnO NP expression profile. ZnO NPs effected expression of genes involved in cytoskeletal transport, cellular respiration, and reproduction. A specific pattern of differential expression of three biomarker genes including a multicystatin, ferritin, and C1q containing gene were confirmed for ZnO NP exposure and provide a suite of biomarkers for identifying environmental exposure to ZnO NPs and differentiating between NP and ionic exposure.
SN - 1520-5851
UR - https://www.unboundmedicine.com/medline/citation/21142172/Differential_gene_expression_in_Daphnia_magna_suggests_distinct_modes_of_action_and_bioavailability_for_ZnO_nanoparticles_and_Zn_ions_
L2 - https://doi.org/10.1021/es102501z
DB - PRIME
DP - Unbound Medicine
ER -